147085-13-0

Basic information

• Product Name: 1,2,5-Oxadiazole-3-carboxiMidoyl chloride, 4-aMino-N-hydroxy-
• Synonyms: 4-aMino-N'-hydroxy-1,2,5-oxadiazole-3-carboxiMidoyl chloride;4-[chloro(nitroso)methylidene]-1,2,5-oxadiazol-3-amine;Furazancarboximidoyl chloride, 4-amino-N-hydroxy-;4-amino-N-hydroxy-1,2,5-oxadiazole-3-carboximidamidoyl chloride;(E)-4-Amino-N-Hydroxy-1,2,5-Oxadiazole-3-Carbimidoyl Chloride;1,2,5-Oxadiazole-3-carboxiMidoyl chloride, 4-aMino-N-hydroxy-;(Z)-4-amino-N-hydroxy-1,2,5-oxadiazole-3-carbonimidoyl chloride;4-Amino-N-hydroxy-1,2,5-oxadiazole-3-carbimidoyl chloride
• CAS NO: 147085-13-0
• Molecular Formula: C₃H₃ClN₄O₂
• Molecular Weight: 162.53452
• Mol File: 147085-13-0.mol
• Article Data: 51

Chemical Properties

• Boiling Point: 398.0±52.0 °C(Predicted)
• Appearance: /
• Density: 2.13±0.1 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 9.19±0.70(Predicted)
• CAS DataBase Reference: 1,2,5-Oxadiazole-3-carboxiMidoyl chloride, 4-aMino-N-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,5-Oxadiazole-3-carboxiMidoyl chloride, 4-aMino-N-hydroxy-(147085-13-0)
• EPA Substance Registry System: 1,2,5-Oxadiazole-3-carboxiMidoyl chloride, 4-aMino-N-hydroxy-(147085-13-0)

Safety Data

• Hazardous Substances Data: 147085-13-0(Hazardous Substances Data)

Usage

General Description

1,2,5-Oxadiazole-3-carboximidoyl chloride, 4-amino-N-hydroxy- is a chemical compound with the molecular formula C3H3ClN4O2. It is a highly reactive and potentially dangerous compound, commonly used in the synthesis of pharmaceuticals and other organic compounds. 1,2,5-Oxadiazole-3-carboximidoyl chloride, 4-amino-N-hydroxy- is used as a reagent in the synthesis of oxadiazole derivatives, which have a wide range of biological and pharmacological activities. It is also known for its ability to act as a precursor in the production of various functional groups, making it a valuable tool in organic synthesis. However, it is important to handle this compound with caution, as it can pose health hazards if not used properly.

Upstream product

• 13490-32-9 4-amino-N-hydroxy-furazan-3-carboxamidine 
• 1211025-52-3 4-amino-N’-hydroxy-1,2,5-oxadiazole-3-carboximidamide 
• 109-77-3 malononitrile 

Downstream Products

• 914471-09-3 4-amino-N-(3-chloro-4-fluorophenyl)-N‘-hydroxy-1,2,5-oxadiazole-3-carboximidamide 
• 129206-45-7 3-(Dimethylamino)oximinomethyl-4-aminofurazan 

Relevant articles and documents

Synthesis of macrocyclic systems from 4,4'-diamino-3,3'-bi-1,2,5-oxadiazole and 3(4)-amino-4(3)-(4-amino-1,2,5-oxadiazol-3-yl)-1,2,5-oxadiazole 2-oxides

Oxidative cyclocondensation of 4,4'-diamino-3,3'-bi-1,2,5-oxadiazole and isomeric 3(4)-amino-4(3)-(4-amino-1,2,5-oxadiazol-3-yl)-1,2,5-oxadiazole 2-oxides under the action of dibro-moisocyanurate gave 12- and 18-membered macrocyclic systems containing two or three bifurazanyl or furazanylfuroxanyl moieties linked by azo bridges. The latter were oxidized into azoxy groups with Caro's acid in 20% oleum.

Oxadiazole derivative, preparation method and applications thereof

The invention relates to an oxadiazole derivative, a preparation method and applications thereof, wherein the oxadiazole derivative has a structure represented by a formula (I), and R1, X and R2 are defined in the specification.

2,3-dioxygenase inhibitor containing thio four-membered ring structure as well as preparation method and application of 2, 3-dioxygenase inhibitor

The invention belongs to the field of drug synthesis, and relates to a 1,2,5-oxadiazole compound containing a thio four-membered ring shown in a general formula (I) and pharmaceutically acceptable salts thereof, and a preparation method and medical applic

Finding furoxan rings

A furoxan ring is derived from a dinitromethyl group. A plausible mechanism is proposed based on 1H, 13C and 15N NMR spectral analysis where a dinitromethyl group releases one molecule of nitric acid to form an unstable nitrile oxide and its dipole isomer which cyclize to a furoxan ring [3,4-bis(4-nitro-1,2,5-oxadizaol-3-yl)-1,2,5-oxadiazole-N-oxide (5)]. This new method of constructing a furoxan (1,2,5-oxadiazole 2-oxide) ring offers a potentially efficient way to obtain excellent energetic materials. In order to stabilize the dinitromethyl-containing precursor [3-(dinitromethyl)-4-nitro-1,2,5-oxadiazole (4)], a series of new energetic salts was synthesized and fully characterized. These materials exhibit high densities, excellent detonation properties and acceptable sensitivities. For example, the hydrazinium salt 9 has a high density of 1.92 g cm-3, a detonation velocity of 9437 m s-1 and a detonation pressure of 41.3 GPa, which approach those properties of CL-20 (ρ, 2.03 g cm-3; vD, 9406 m s-1; P, 44.6 GPa) and which are superior to those of HMX (ρ, 1.90 g cm-3; vD, 9320 m s-1; P, 39.2 GPa).