147284-80-8Relevant articles and documents
Nonpeptidic Inhibitors of Human Leukocyte Elastase. 3. Design, Synthesis, X-ray Crystallographic Analysis, and Structure-Activity Relationships for a Series of Orally Active 3-Amino-6-phenylpyridin-2-one Trifluoromethyl Ketones
Bernstein, Peter R.,Andisik, Don,Bradley, Prudence K.,Bryant, Craig B.,Ceccarelli, Christopher,et al.
, p. 3313 - 3326 (2007/10/02)
A series of nonpeptidic inhibitors of human leukocyte elastase (HLE) is reported.These trifluoromethyl ketone-based inhibitors contain a 3-amino-6-phenylpyridone group as a central template.The effect of varying the N-3 substituent in these inhibitors on