147359-76-0

Basic information

• Product Name: Flibanserin Hydrochloride
• Synonyms: Flibanserin Hydrochloride;Flibanserin HCl
• CAS NO: 147359-76-0
• Molecular Formula: C₂₀H₂₁F₃N₄O*ClH
• Molecular Weight: 426.8630896
• EINECS: 1592732-453-0
• Mol File: 147359-76-0.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: Flibanserin Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Flibanserin Hydrochloride(147359-76-0)
• EPA Substance Registry System: Flibanserin Hydrochloride(147359-76-0)

Safety Data

• Hazardous Substances Data: 147359-76-0(Hazardous Substances Data)

Usage

Description

Flibanserin Hydrochloride is a pharmaceutical compound that acts as a 5-HT1A agonist and a 5-HT2A antagonist. It is primarily developed for the treatment of hypoactive sexual desire disorder in women, a condition characterized by a persistent or recurring deficiency in sexual fantasies and desire for sexual activity.

Uses

Used in Pharmaceutical Industry:
Flibanserin Hydrochloride is used as a therapeutic agent for the treatment of hypoactive sexual desire disorder (HSDD) in women. It works by modulating the levels of serotonin in the brain, which is believed to influence sexual desire and arousal. The compound's dual action as a 5-HT1A agonist and 5-HT2A antagonist helps to increase sexual desire and satisfaction in women suffering from HSDD.
In addition to its primary application, Flibanserin Hydrochloride may also have potential uses in other areas of medicine, such as the treatment of sexual dysfunction in men or other conditions related to serotonin regulation. However, further research and clinical trials would be necessary to establish its efficacy and safety in these contexts.

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Downstream Products

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Relevant articles and documents

A Facile Route of Synthesis for Making Flibanserin

A novel and efficient route of synthesis for making flibanserin via 2-ethoxy-1H-benzo[d]imidazole (12) was described with excellent yield. This protocol provided a more facile approach to flibanserin.

A preparation method of flibanserin (by machine translation)

The invention discloses a method for preparing of flibanserin, includes the steps of: (1) compound I with dichloroethane reaction to obtain compound II, its without purification, directly with compound III reaction, to obtain the compound IV; (2) compound

NOVEL POLYMORPHS OF FLIBANSERIN HYDROCHLORIDE

The present invention provides novel crystalline anhydrous form II, hemihydrate form III, anhydrous form IV, anhydrous form V, anhydrous form VI, hemihydrate form VII, hemihydrate form VIII, hemihydrate form IX and amorphous form of flibanserin hydrochloride, processes for its preparation and to pharmaceutical compositions containing them.