1474024-68-4

Basic information

• Product Name: 4-((S)-1-((R)-2-(2,4-difluorophenyl)oxirane-2-yl)ethyl)-5-fluoropyrimidine
• Synonyms: 4-((S)-1-((R)-2-(2,4-difluorophenyl)oxirane-2-yl)ethyl)-5-fluoropyrimidine
• CAS NO: 1474024-68-4
• Molecular Weight: 280.249
• Mol File: 1474024-68-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-((S)-1-((R)-2-(2,4-difluorophenyl)oxirane-2-yl)ethyl)-5-fluoropyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-((S)-1-((R)-2-(2,4-difluorophenyl)oxirane-2-yl)ethyl)-5-fluoropyrimidine(1474024-68-4)
• EPA Substance Registry System: 4-((S)-1-((R)-2-(2,4-difluorophenyl)oxirane-2-yl)ethyl)-5-fluoropyrimidine(1474024-68-4)

Safety Data

• Hazardous Substances Data: 1474024-68-4(Hazardous Substances Data)

Upstream product

• 861718-85-6 3-chloro-2-(2,4-difluorophenyl)-2-(trimethylsilanyloxy)propionaldehyde 
• 1474024-67-3 (R)-4-(1-(2-(2,4-difluorophenyl)oxirane-2-yl)vinyl)-5-fluoropyrimidine 
• 1474024-66-2 (R)-(2-(2,4-difluorophenyl)oxiran-2-yl)(5-fluoropyrimidin-4-yl)-methanone 
• 1474024-65-1 (R)-((R)-2-(2,4-difluorophenyl)oxiran-2-yl)(5-fluoropyrimidin-4-yl)methanol 

Downstream Products

• 1028563-65-6 (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(4H-1,2,4-triazol-4-yl)butan-2-ol 
• 137234-63-0 (2S,3R)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 137234-62-9 voriconazole 
• 1474024-76-4 (3R)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-2-(4H-1,2,4-triazol-4-yl)butan-1-ol 
• 1474024-71-9 (E)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)but-2-en-1-ol 
• 1474024-75-3 7-(2,4-difluorophenyl)-8-methyl-6H-pyrano[3,2-d]pyrimidine 

Relevant articles and documents

COMPOUND AND METHOD FOR MANUFACTURING THE SAME, AND METHOD FOR MANUFACTURING VORICONAZOLE

PROBLEM TO BE SOLVED: To provide a method for manufacturing voriconazole, which is a therapeutic agent for severe or intractable deep mycosis such as aspergillosis, allowing easy manufacture without the need for the optical resolution. SOLUTION: A method for manufacturing voriconazole includes: obtaining a compound represented by the general formula (3) by using catalytic asymmetric cyanoacylation reaction; and reacting the compound with 1,2,4-triazole to convert it into voriconazole. [In the general formula (3), X is any of the divalent groups represented by the specified structural formulas.] COPYRIGHT: (C)2015,JPOandINPIT