14742-36-0

Basic information

• Product Name: 3,4,5,6-TETRAFLUORO-2-HYDROXYBENZOIC ACID
• Synonyms: 3,4,5,6-TETRAFLUORO-2-HYDROXYBENZOIC ACID;3,4,5,6-TETRAFLUOROSALICYLIC ACID;2,3,4,5-Tetrafluoro-6-hydroxybenzoic acid
• CAS NO: 14742-36-0
• Molecular Formula: C₇H₂F₄O₃
• Molecular Weight: 210.08
• Mol File: 14742-36-0.mol
• Article Data: 7

Chemical Properties

• Melting Point: 173 °C
• Boiling Point: 282.1 °C at 760 mmHg
• Flash Point: 124.4 °C
• Appearance: /
• Density: 1.792 g/cm³
• Vapor Pressure: 0.00162mmHg at 25°C
• Refractive Index: 1.509
• PKA: 1.53±0.28(Predicted)
• CAS DataBase Reference: 3,4,5,6-TETRAFLUORO-2-HYDROXYBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4,5,6-TETRAFLUORO-2-HYDROXYBENZOIC ACID(14742-36-0)
• EPA Substance Registry System: 3,4,5,6-TETRAFLUORO-2-HYDROXYBENZOIC ACID(14742-36-0)

Safety Data

• Statements: 36/37/38
• Safety Statements: 36/37/39
• Hazardous Substances Data: 14742-36-0(Hazardous Substances Data)

Usage

General Description

3,4,5,6-Tetrafluoro-2-hydroxybenzoic acid, also known as TFHBA, is a carboxylic acid compound with the molecular formula C7H3F4O3. It is a white crystalline solid that is soluble in water and organic solvents. TFHBA is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals, as well as in the production of electronic materials. It is also utilized as a building block for the development of fluorescent sensors and dyes. TFHBA is a highly reactive compound that is primarily handled by trained professionals in controlled laboratory environments to ensure safety and proper handling.

InChI:InChI=1/C7H2F4O3/c8-2-1(7(13)14)6(12)5(11)4(10)3(2)9/h12H,(H,13,14)

Upstream product

• 124-38-9 carbon dioxide 
• 3467-85-4 2,3,4,5-tetrafluorophenol 
• 38512-77-5 2,3,4,5-tetrafluoro-6-methoxybenzoic acid 
• 109-88-6 magnesium methanolate 
• 551-62-2 1,2,3,4-tetrafluorobenzene 
• 4487-61-0 5,6,7,8-tetrafluoro-2-methyl-4-oxo-4H-benzopyran-3-carboxylic acid ethyl ester 
• 602-94-8 Pentafluorobenzoic acid 

Downstream Products

• 22105-26-6 2-acetyloxy-3,4,5,6-tetrafluorobenzoic acid 
• 15068-09-4 ethyl 2-hydroxy-3,4,5,6-tetrafluorobenzoate 

Relevant articles and documents

Preparation method of 3,4,5,6-tetrafluorosalicylic acid

The invention discloses a preparation method of 3,4,5,6-tetrafluorosalicylic acid. The preparation method comprises the following steps of adopting 2,3,4,5,6-pentafluorobenzoyl chloride as a raw material, obtaining intermediate products by condensation of the raw material with ethyl acetoacetate and complexation of the condensation products with cupric ions, and acidifying the intermediate products; obtaining 5,6,7,8-tetrafluoro-2-methyl-4-oxo-4H-benzopyran-3-carboxylic ethyl ester by cyclizaiton of the acidified products through heating, stirring the cyclization products in a sodium hydroxide solution, dropwise and slowly adding excessive amount of hydrogen peroxide solution, stirring and preserving the temperature of the mixture, and completing the reaction after the cyclization products are not detected by TLC; removing excessive amount of hydrogen peroxide by adding sodium thiosulfate, increasing the temperature for 1 hour, adjusting pH by adding hydrochloric acid after cooling the mixture to room temperature, and extracting target products with methyl tertiary butyl ether; drying the target products with anhydrous sodium sulfate, distilling the filter liquid, and obtaining 3,4,5,6-tetrafluorosalicylic acid by recrystallization of crude products by using dichloromethane. The preparation method has the advantages of low requirement for equipment, no pollution due to by-products of water, product recovery of 78-83% and crude product purity of 97%.

INHIBITORS OF STEAROYL-COA DESATURASE

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity.