147619-40-7

Basic information

• Product Name: 5-CHLORO-1,2-DIHYDRO-4-METHOXY-2-OXO-3-PYRIDINECARBONITRILE
• Synonyms: 5-CHLORO-1,2-DIHYDRO-4-METHOXY-2-OXO-3-PYRIDINECARBONITRILE;3-Cyano GiMeracil Methyl Ether;5-Chloro-4-Methoxy-2-oxo-1,2-dihydropyridine-3-carbonitrile;5-Chloro-3-Cyano-4-methony-2-(1H)-pyridinone;3-pyridinecarbonitrile, 5-chloro-1,2-dihydro-4-methoxy-2-oxo-;MPC 5-chloro-1,2-dihydro-4-methoxy-2-oxo-3-pyridinecarbonitrile
• CAS NO: 147619-40-7
• Molecular Formula: C₇H₅ClN₂O₂
• Molecular Weight: 184.58
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 147619-40-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 376.845 °C at 760 mmHg
• Flash Point: 181.709 °C
• Appearance: /
• Density: 1.434 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.563
• Storage Temp.: 2-8°C
• Solubility: Dimethyl Sulfoxide, Methanol
• PKA: 5.93±0.10(Predicted)
• CAS DataBase Reference: 5-CHLORO-1,2-DIHYDRO-4-METHOXY-2-OXO-3-PYRIDINECARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-1,2-DIHYDRO-4-METHOXY-2-OXO-3-PYRIDINECARBONITRILE(147619-40-7)
• EPA Substance Registry System: 5-CHLORO-1,2-DIHYDRO-4-METHOXY-2-OXO-3-PYRIDINECARBONITRILE(147619-40-7)

Safety Data

• Hazardous Substances Data: 147619-40-7(Hazardous Substances Data)

Usage

Chemical Properties

Light Yellow Solid

Uses

Different sources of media describe the Uses of 147619-40-7 differently. You can refer to the following data:
1. 3-Cyano Gimeracil Methyl Ether is a useful Intermediate in the synthesis of the antitumor agent Gimeracil.
2. Intermediate in the synthesis of antitumor agent Gimeracil.

InChI:InChI=1/C7H5ClN2O2/c1-12-6-4(2-9)7(11)10-3-5(6)8/h3H,1H3,(H,10,11)

Upstream product

• 95689-38-6 1,1-dicyano-4-(N,N-dimethylamino)-2-methoxy-1,3-butadiene 
• 21642-98-8 4-methoxy-2-oxo-1,2-dihydropyridine-3-carbonitrile 

Downstream Products

• 103766-25-2 5-chloro-4-hydroxy-2(1H)-pyridinone 

Relevant articles and documents

A high-purity medicinal gemmezine production process

The present invention discloses a high purity medicinal gemmezine production process. The present invention takes malonitrile and trimethyl orthoxyacetate as the starting material, by condensation reaction, cyclization reaction, chlorination reaction and hydrolysis reaction to obtain gemmepyrimidine, wherein the present invention does not distill sulfonyl chloride and acetic acid in the chlorination step, cooling crystallization after the addition of methanol pulp refining; hydrolysis step using sulfuric acid to remove methyl and cyanogen without concentration directly adjust pH precipitation, and then using absolute ethanol refining, after the use of the above process, reduce the corrosion of equipment and pipelines, and 4-Me-CDHP, N-Me-CDHP, CN-CDEP and other unknown monozythic content is controlled at ≤0.03%, which is more suitable for the needs of industrial production of high-purity meperidine.

A lucky US pyrimidine synthesis method (by machine translation)

The invention belongs to the technical field of chemical synthesis, in particular to a lucky US pyrimidine synthesis method. The method will be the 3 - cyano - 4 - methoxy - 2 - H - pyridone with sulfonic acid chloride in glacial acetic acid in the separated after the reaction to the 3 - cyano - 4 - methoxy - 5 - chloro 2 - (1H) pyridone; the 3 - cyano - 4 - methoxy - 5 - chloro 2 - (1H) pyridone with hydrobromic acid to obtain lucky US pyrimidine. The invention provides a method for the preparation of pyrimidine lucky US, simple operation, cycle is short, low cost, good product purity, easy product of large-scale production. (by machine translation)

CONVENIENT AND PRACTICAL SYNTHESIS OF 5-CHLORO-4-HYDROXY-2(1H)-PYRIDINONE

5-Chloro-4-hydroxy-2(1H)-pyridinone (1) was prepared by 4-step reactions via the key intermediate 5-chloro-3-cyano-4-methoxy-2(1H)-pyridinone (5).This synthetic route has several advantages over the reported methods in procedure, yield and applicability.