1477517-19-3

Basic information

• Product Name: (2R,3R)-3-(tert-butyl)-4-(2, 6-dimethoxyphenyl)-2-iso propyl-2,3-dihydrobenzo[d ][1,3]oxaphosphole
• Synonyms: (2R,3R)-3-(tert-butyl)-4-(2, 6-dimethoxyphenyl)-2-iso propyl-2,3-dihydrobenzo[d ][1,3]oxaphosphole
• CAS NO: 1477517-19-3
• Molecular Formula: C₂₂H₂₉O₃P
• Molecular Weight: 372.437621
• Product Categories: Chiral Phosphine
• Mol File: 1477517-19-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 451.5±45.0 °C(Predicted)
• Appearance: light-yellow/crystal
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: (2R,3R)-3-(tert-butyl)-4-(2, 6-dimethoxyphenyl)-2-iso propyl-2,3-dihydrobenzo[d ][1,3]oxaphosphole(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3R)-3-(tert-butyl)-4-(2, 6-dimethoxyphenyl)-2-iso propyl-2,3-dihydrobenzo[d ][1,3]oxaphosphole(1477517-19-3)
• EPA Substance Registry System: (2R,3R)-3-(tert-butyl)-4-(2, 6-dimethoxyphenyl)-2-iso propyl-2,3-dihydrobenzo[d ][1,3]oxaphosphole(1477517-19-3)

Safety Data

• Hazardous Substances Data: 1477517-19-3(Hazardous Substances Data)

Usage

Reaction

Ligand/palladium catalyst for asymmetric Suzuki-Miyaura cross-coupling reactions

Upstream product

• 1477517-23-9 C₂₂H₂₉O₄P 
• 1338453-99-8 (S)-3-(tert-butyl)-4-(2,6-dimethoxyphenyl)-2H-benzo[d][1,3]oxaphosphole 3-oxide 
• 1338453-95-4 (S)-3-tert-butyl-2,3-dihydrobenzo[d][1,3]oxaphosphol-4-yl trifluoromethanesulfonate oxide 
• 23112-96-1 (2,6-dimethoxyphenyl)boronic acid 

Relevant articles and documents

Efficient syntheses of korupensamines A, B and michellamine B by asymmetric Suzuki-Miyaura coupling reactions

Efficient asymmetric Suzuki-Miyaura coupling reactions are employed for the first time in total syntheses of chiral biaryl natural products korupensamine A and B in combination with an effective diastereoselective hydrogenation, allowing ultimately a concise and stereoselective synthesis of michellamine B. Chiral monophosphorus ligands L1-3 are effective for the syntheses of a series of functionalized chiral biaryls by asymmetric Suzuki-Miyaura coupling reactions in excellent yields and enantioselectivities (up to 99% ee). The presence of a polar-π interaction between the highly polarized BOP group and the extended π system of arylboronic acid coupling partner is believed to be important for the high enantioselectivity.