147780-58-3

Basic information

• Product Name: (3S,5S)-3-benzyl-5-phenyl-3,4,5,6-tetrahydro-1,4-oxazin-2-one
• Synonyms: (3S,5S)-3-benzyl-5-phenyl-3,4,5,6-tetrahydro-1,4-oxazin-2-one
• CAS NO: 147780-58-3
• Molecular Weight: 267.327
• Mol File: 147780-58-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (3S,5S)-3-benzyl-5-phenyl-3,4,5,6-tetrahydro-1,4-oxazin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3S,5S)-3-benzyl-5-phenyl-3,4,5,6-tetrahydro-1,4-oxazin-2-one(147780-58-3)
• EPA Substance Registry System: (3S,5S)-3-benzyl-5-phenyl-3,4,5,6-tetrahydro-1,4-oxazin-2-one(147780-58-3)

Safety Data

• Hazardous Substances Data: 147780-58-3(Hazardous Substances Data)

Upstream product

• 147700-91-2 (5S)-2,3,5,6-tetrahydro-5-phenyl-N-(benzyloxycarbonyl)-4H-1,4-oxazin-2-one 
• 100-39-0 benzyl bromide 
• 144896-92-4 (5S)-5-phenylmorpholin-2-one 
• 6479-55-6 L-phenylalanine phenacyl ester hydrobromide 
• 65085-99-6 (S)-3-benzyl-5-phenyl-3,6-dihydro-[1,4]oxazin-2-one 
• 183023-15-6 (S)-5-phenyl-5,6-dihydro-2H-1,4-oxazin-2-one 

Downstream Products

• 63-91-2 L-phenylalanine 

Relevant articles and documents

Synthesis of enantiomerically pure α-amino acids via chemo- and diastereoselective alkylation of (5S)-5-phenyl-5,6-dihydro-2H-1,4-oxazin-2-one

(5S)-5-Phenyl-5,6-dihydro-2H-1,4-oxazin-2-one 2 undergoes Lewis acid-mediated chemo- and diastereoselective nucleophilic addition of Grignard reagents to furnish adducts 3 which can be dismantled to allow ready access to enantiomerically pure (S)-α-amino acids 4.