14793-00-1

Basic information

• Product Name: IMIDAZO[1,2-B]PYRIDAZINE, 6-CHLORO-2-METHYL-
• Synonyms: 6-chloro-2-Methly-iMidazo [1, 2-b] pyridazine;6-chloro-2-Methyl-iMidazopyridazine;IMIDAZO[1,2-B]PYRIDAZINE, 6-CHLORO-2-METHYL-;6-CHLORO-2-METHYLIMIDAZO[1,2-B]PYRIDAZINE;2-Methyl-6-chloroiMidazo[1,2-b]pyridazine;6-chloro-2-methylimidazo[1,2-b]pyridazine 97%
• CAS NO: 14793-00-1
• Molecular Formula: C₇H₆ClN₃
• Molecular Weight: 167.6
• Mol File: 14793-00-1.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• Density: 1.43
• Refractive Index: 1.681
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 4.70±0.30(Predicted)
• CAS DataBase Reference: IMIDAZO[1,2-B]PYRIDAZINE, 6-CHLORO-2-METHYL-(CAS DataBase Reference)
• NIST Chemistry Reference: IMIDAZO[1,2-B]PYRIDAZINE, 6-CHLORO-2-METHYL-(14793-00-1)
• EPA Substance Registry System: IMIDAZO[1,2-B]PYRIDAZINE, 6-CHLORO-2-METHYL-(14793-00-1)

Safety Data

• Hazardous Substances Data: 14793-00-1(Hazardous Substances Data)

Usage

General Description

IMIDAZO[1,2-B]PYRIDAZINE, 6-CHLORO-2-METHYL- is a chemical compound that belongs to the imidazopyridazine family. It is characterized by a six-membered imidazo ring fused to a five-membered pyridazine ring, with a chlorine atom at the sixth position and a methyl group at the second position. IMIDAZO[1,2-B]PYRIDAZINE, 6-CHLORO-2-METHYL- has potential applications in medicinal chemistry, particularly in the development of pharmaceutical drugs. Its structural features make it a promising candidate for the synthesis of bioactive molecules, including potential anti-cancer, anti-inflammatory, and anti-microbial agents. Further research and exploration of its chemical properties and biological activities are warranted to fully understand its potential therapeutic uses.

InChI:InChI=1/C7H6ClN3/c1-5-4-11-7(9-5)3-2-6(8)10-11/h2-4H,1H3

Upstream product

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• 1208069-63-9 {4-[6-(5-benzylhexahydropyrrolo[3,4-c]pyrrol-2-yl)-2-methylimidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl}methylamine 
• 1083429-59-7 N-(2-{4-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-2-methoxy-phenoxy}-ethyl)-4-morpholin-4-yl-benzamide 
• 1083429-55-3 1-(3-{5-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-2-methoxy-phenoxy}-propyl)-3-(3-methoxy-phenyl)-urea 

Relevant articles and documents

INHIBITORS OF LIN28 AND METHODS OF USE THEREOF

The present disclosure relates to compounds of formula (I) and compositions comprising the same. The disclosure further relates to methods of treating cancers.

IMIDAZOPYRIDAZINE DERIVATIVES AS ΡΙ3Κβ INHIBITORS

The present invention relates to substituted imidazopyridazine derivatives of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as pΙ3Κβ inhibitors. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

COMBINATION OF KINASE INHIBITORS AND USES THEREOF

The present invention provides for a method for treating a disease condition associated with PI3-kinase a and/or a receptor tyrosine kinase (RTK) in a subject. In another aspect, the invention provides for a method for treating a disease condition associated with PI3-kinase α and/or an RTK in a subject. In yet another aspect, a method of inhibiting phosphorylation of Akt (S473) in a cell is set forth.