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148-01-6

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148-01-6 Usage

Chemical Properties

Yellowish solid. Very slightly soluble in water; soluble in acetone, acetonitrile, dioxane, and dimethylformamide.

Uses

Different sources of media describe the Uses of 148-01-6 differently. You can refer to the following data:
1. Dinitolmide may be used as an analytical reference standard for the quantification of the analyte in animal tissues poultry, livestock, and aquatic tissues using chromatography techniques.
2. A fodder additive for poultry used to prevent coccidiosis infections. Antiprotozoan drug.
3. antiprotozoal

General Description

Yellowish, crystalline solid. Mp: 177°C. Very slightly soluble in water. Soluble in acetone, acetonitrile, and dimethylformamide. Used as an anti-parasite drug for poultry. Store in a cool, ventilated place, away from acute fire hazards and easily oxidized materials.

Reactivity Profile

Dinitolmide reacts as an oxidizing agent. Has been known on at least one occasion to explode destructively. Incompatible with easily oxidized materials. Emits toxic NOx fumes if heated to decomposition.

Hazard

Liver damage

Safety Profile

Poison by intravenous route. Moderately toxic by ingestion. Mutation data reported. A strong exothermic reaction above 248OC has caused industrial explosions. When heated to decomposition it emits toxic fumes of NOx. See also NITRO COMPOUNDS of AROMATIC HYDROCARBONS.

Check Digit Verification of cas no

The CAS Registry Mumber 148-01-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,4 and 8 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 148-01:
(5*1)+(4*4)+(3*8)+(2*0)+(1*1)=46
46 % 10 = 6
So 148-01-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H7N3O5/c1-4-6(8(9)12)2-5(10(13)14)3-7(4)11(15)16/h2-3H,1H3,(H2,9,12)

148-01-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 3,5-Dinitro Toluamide

1.2 Other means of identification

Product number -
Other names 2-methyl-3,5-dinitrobenzamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:148-01-6 SDS

148-01-6Synthetic route

2-methyl-3,5-dinitro-benzoyl chloride
39614-85-2

2-methyl-3,5-dinitro-benzoyl chloride

zoalene
148-01-6

zoalene

Conditions
ConditionsYield
With ammonium hydroxide; ammonium bicarbonate at 40℃; for 0.5h; Large scale;85.9%
With ammonium hydroxide
Multi-step reaction with 2 steps
1: ethanol
2: aqueous ammonia
View Scheme
With ammonium hydroxide In dichloromethane at 0℃; for 1.5h;
2-methyl-3,5-dinitrobenzoic acid ethyl ester
854646-60-9

2-methyl-3,5-dinitrobenzoic acid ethyl ester

zoalene
148-01-6

zoalene

Conditions
ConditionsYield
With ammonium hydroxide
ortho-methylbenzoic acid
118-90-1

ortho-methylbenzoic acid

zoalene
148-01-6

zoalene

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sulfuric acid; nitric acid
2: phosphorus (V)-chloride
3: ethanol
4: aqueous ammonia
View Scheme
Multi-step reaction with 3 steps
1: sulfuric acid; nitric acid
2: phosphorus (V)-chloride
3: aqueous ammonia
View Scheme
Multi-step reaction with 3 steps
1: sulfuric acid; nitric acid / Large scale
2: thionyl chloride / Large scale
3: ammonium hydroxide; ammonium bicarbonate / 0.5 h / 40 °C / Large scale
View Scheme
3,5-dinitro-o-toluic acid
28169-46-2

3,5-dinitro-o-toluic acid

zoalene
148-01-6

zoalene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: phosphorus (V)-chloride
2: ethanol
3: aqueous ammonia
View Scheme
Multi-step reaction with 2 steps
1: phosphorus (V)-chloride
2: aqueous ammonia
View Scheme
Multi-step reaction with 2 steps
1: thionyl chloride; sulfuric acid / 0.23 h / Inert atmosphere; Reflux
2: ammonium hydroxide / dichloromethane / 1.5 h / 0 °C
View Scheme
zoalene
148-01-6

zoalene

3-phenyl-propenal
104-55-2

3-phenyl-propenal

ethyl (triphenylphosphoranylidene)acetate
1099-45-2

ethyl (triphenylphosphoranylidene)acetate

(S,E)-ethyl 6-(2-carbamoyl-4,6-dinitrophenyl)-5-phenylhex-2-enoate

(S,E)-ethyl 6-(2-carbamoyl-4,6-dinitrophenyl)-5-phenylhex-2-enoate

Conditions
ConditionsYield
Stage #1: zoalene; 3-phenyl-propenal With (S)-2-(((tert-butyldimethylsilyl)oxy)diphenylmethyl)pyrrolidine; dmap In acetonitrile at 40℃; for 48h;
Stage #2: ethyl (triphenylphosphoranylidene)acetate In acetonitrile at 0 - 20℃; for 2h; enantioselective reaction;
40%
zoalene
148-01-6

zoalene

2-amino-4,6-dinitrotoluene
35572-78-2

2-amino-4,6-dinitrotoluene

Conditions
ConditionsYield
With sodium hypochlorite und Erwaermen des Reaktionsprodukts mit Wasser;
zoalene
148-01-6

zoalene

A

3-amino-5-nitro-o-toluamide
90223-31-7

3-amino-5-nitro-o-toluamide

B

5-amino-3-nitro-o-toluamide
3572-44-9

5-amino-3-nitro-o-toluamide

Conditions
ConditionsYield
With palladium on activated charcoal; cyclohexene In ethanol at 51℃;

148-01-6Related news

Effect of Dinitolmide (cas 148-01-6) intercalated into Montmorillonite on E. tenella infection in chickens09/29/2019

To enhance the anti-coccidial effect of dinitolmide and reduce its residual, the dinitolmide/MMT compounds were synthesized by the method of solution intercalation via dinitolmide intercalated into Na + -montmorillonite (Na + -MMT). The structure of compounds was characterized by X-ray diffracti...detailed

Development of an ASE‐GC‐MS/MS method for detecting Dinitolmide (cas 148-01-6) and its metabolite 3‐ANOT in eggs09/28/2019

An accelerated solvent extraction coupled with gas chromatography‐tandem mass spectrometry (ASE‐GC‐MS/MS) method for detecting dinitolmide residue and its metabolite (3‐amino‐2‐methyl‐5‐nitrobenzamide, 3‐ANOT) in eggs was developed and optimized. The samples were extracted using ASE wit...detailed

148-01-6Relevant articles and documents

Br?nsted acid-catalyzed chlorination of aromatic carboxylic acids

Yu, Zhiqun,Yao, Hongmiao,Xu, Qilin,Liu, Jiming,Le, Xingmao,Ren, Minna

, p. 685 - 689 (2021/04/09)

The chlorination of aromatic carboxylic acids with SOCl2 has been effectively performed by reacting with a Br?nsted acid as the catalyst. Based on this discovery, an efficient catalytic method that is cheaper than traditional catalytic methods was developed. 20 substrates were chlorinated offering excellent yields in a short reaction time. And the SOCl2/Br?nsted acid system has been used in a larger scale preparative reaction. A dual activation mechanism was proposed to prove the irreplaceable system of SOCl2/Br?nsted acid.

Process for formulating a synthetic drug for use in animal feed, and resulting formulation

-

, (2008/06/13)

A method of formulating a synthetic drug for use in animal feed, for the purpose of reducing carry-over of the synthetic drug to subsequent lots of animal feed in the feed mill.

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