148-53-8Relevant articles and documents
Asymmetric Henry reaction catalyzed by a copper tridentate chiral schiff-base complex
Lai, Guoyin,Wang, Sujing,Wang, Zhiyong
, p. 1813 - 1819 (2008)
A series of copper-tridentate chiral Schiff-base complexes were prepared and employed in an asymmetric Henry reaction, affording the corresponding adducts in good yields and with high enantioselectivities (up to 96% ee).
ortho-Hydroxylation of Aromatic Aldehydes: A Short Synthesis of 2-Hydroxypyrene-1-carbaldehyde
Einhorn, Jacques,Luche, Jean-Louis,Demerseman, Pierre
, p. 1350 - 1352 (1988)
A new methodology for the ortho-hydroxylation of aromatic aldehydes via ortho-lithiated aromatic amino alkoxides provides easy access to 2-hydroxypyrene-1-carbaldehyde, a valuable precursor for biologically important pyrenofurans and pyrenocoumarins.
Enantioselective Hydroboration of Ketones Catalyzed by Rare-Earth-Metal Complexes Supported with Phenoxy-Functionalized TsDPEN Ligands
Yu, Qishun,Lu, Chengrong,Zhao, Bei
supporting information, p. 2529 - 2537 (2021/07/28)
Six novel chiral rare-earth-metal complexes bearing the phenoxy-functionalized TsDPEN ligand H3L1 (H3L1 = N-((1R,2R)-2-((3,5-di-Tert-butyl-2-hydroxybenzyl)amino)-1,2-diphenylethyl)-4-methylbenzenesulfonamide) were synthesized successfully and well characterized. The solid-state structures of four tetranuclear rare-earth-metal complexes [RE2L13]2 (RE = Nd (1), Sm (2), Eu (3), Gd (4)) and the dual-core yttrium complex Y2L13 (5) were determined by X-ray diffraction, respectively. The structure of lanthanum complex 6 was speculated by the 1H DOSY spectroscopy in THF-d8 together with DFT calculations. Complexes 1-5 were employed to catalyze the enantioselective hydroboration of ketones and α,β-unsaturated ketones using pinacolborane (HBpin) as a reductant, and complex 1 gave better outcomes in comparison to the others. The corresponding secondary alcohols were obtained in excellent yields and moderate ee values. The same results were also achieved using the combined catalyst system of the neodymium amide Nd[N(SiMe3)2]3 with the phenoxy-functionalized TsDPEN ligand H3L1 in a 1:1.5 molar ratio.
Iron-catalyzed arene C-H hydroxylation
Cheng, Lu,Wang, Huihui,Cai, Hengrui,Zhang, Jie,Gong, Xu,Han, Wei
, p. 77 - 81 (2021/10/05)
The sustainable, undirected, and selective catalytic hydroxylation of arenes remains an ongoing research challenge because of the relative inertness of aryl carbon-hydrogen bonds, the higher reactivity of the phenolic products leading to over-oxidized by-products, and the frequently insufficient regioselectivity. We report that iron coordinated by a bioinspired L-cystine-derived ligand can catalyze undirected arene carbon-hydrogen hydroxylation with hydrogen peroxide as the terminal oxidant. The reaction is distinguished by its broad substrate scope, excellent selectivity, and good yields, and it showcases compatibility with oxidation-sensitive functional groups, such as alcohols, polyphenols, aldehydes, and even a boronic acid. This method is well suited for the synthesis of polyphenols through multiple carbon-hydrogen hydroxylations, as well as the late-stage functionalization of natural products and drug molecules.
Method for preparing aldehyde compounds through photocatalytic oxidation cracking β - hydroxyl compound C-C bond
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Paragraph 0078-0079, (2020/07/29)
The invention provides a method for preparing aldehydes from C-C bonds of beta-hydroxy compounds by photocatalytic oxidative cracking. According to the method, the beta-hydroxy compounds are taken asa substrate, oxygen-containing gas is taken as an oxygen source, and C-C bond cracked products, namely, corresponding aldehydes can be generated under illumination in presence of a catalyst. The conditions are mild, the oxidation efficiency and the product yield are high, and the oxygen-containing gas is taken as the oxygen source under the illumination condition, so that the method is economical,environmentally friendly and green, meets the strategy of sustainable developed energy and has broad application prospect.