1481-11-4

Basic information

• Product Name: 1,1,1,3,3,3-HEXAFLUORO-2-(4-(METHYLAMINO)PHENYL)PROPAN-2-OL
• Synonyms: 1,1,1,3,3,3-HEXAFLUORO-2-(4-(METHYLAMINO)PHENYL)PROPAN-2-OL;1,1,1,3,3,3-Hexafluoro-2-[4-(Methylamino)Phenyl]-2-Propanol
• CAS NO: 1481-11-4
• Molecular Formula: C₁₀H₉F₆NO
• Molecular Weight: 0
• Mol File: 1481-11-4.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,1,1,3,3,3-HEXAFLUORO-2-(4-(METHYLAMINO)PHENYL)PROPAN-2-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1,1,3,3,3-HEXAFLUORO-2-(4-(METHYLAMINO)PHENYL)PROPAN-2-OL(1481-11-4)
• EPA Substance Registry System: 1,1,1,3,3,3-HEXAFLUORO-2-(4-(METHYLAMINO)PHENYL)PROPAN-2-OL(1481-11-4)

Safety Data

• Hazardous Substances Data: 1481-11-4(Hazardous Substances Data)

Usage

Fluorinated alcohol

Yes
The presence of fluorine atoms in the molecule classifies it as a fluorinated alcohol, which can have unique properties compared to non-fluorinated alcohols.

Substituent

4-(methylamino)phenyl
This group is attached to the main carbon chain, providing additional functionality and reactivity to the molecule.

Applications

Pharmaceutical and organic chemistry
The compound is used as a reagent and building block for the synthesis of various organic compounds, particularly in the development of new drugs and pharmaceuticals.

Use as a solvent

Yes
It can be used as a solvent in some chemical processes, likely due to its unique properties as a fluorinated alcohol.

Stability

High
The compound is known for its stability, which is an important factor when considering its use in chemical reactions and as a building block for other compounds.

Inertness

High
The compound's inertness makes it a valuable tool in the development of new chemical compounds and drugs, as it is less likely to react with other substances in unintended ways.

Structure

The molecule consists of a central propane chain with fluorine atoms at the 1,1,1,3,3,3 positions, an alcohol hydroxyl group at the 2 position, and a 4-(methylamino)phenyl substituent attached to the 2-carbon.

Physical state

Likely a liquid or solid at room temperature
While the exact physical state is not provided, fluorinated alcohols typically have higher boiling points and melting points than their non-fluorinated counterparts, which suggests that this compound may be a liquid or solid at room temperature.

Reactivity

Moderate to low
The compound's stability and inertness suggest that it may have moderate to low reactivity, making it suitable for use as a building block in the synthesis of more complex molecules.

Upstream product

• 6628-07-5 N-allyl-N-methylaniline 
• 684-16-2 Hexafluoroacetone 
• 920-66-1 1,1,1,3',3',3'-hexafluoro-propanol 
• 100-61-8 N-methylaniline 
• 96569-49-2 4-(1,1,1,3,3,3-hexafluoro-2-hydroxy-2-propyl)-N-allyl-N-methylaniline 

Downstream Products

• 1073143-34-6 C₁₇H₁₂F₆INO₂ 
• 1395060-13-5 2-(3-bromo-4-(methylamino)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol 
• 1395060-19-1 C₁₂H₁₁F₆NO 
• 1395060-26-0 C₁₉H₁₄F₆INO₂ 
• 1628710-00-8 C₁₇H₁₅F₆NO₄S 
• 1628710-01-9 C₁₇H₁₅F₆NO₃S 
• 1628710-04-2 C₁₆H₁₂BrF₆NO₃S 
• 293753-06-7 [3H]-⁽¹⁴⁴⁾T₀₃₀₇ 
• 1628775-61-0 C₁₅H₁₁F₆NO₂S 
• 1628775-60-9 C₁₅H₁₁F₆NO₂S 
• 1628775-59-6 C₁₆H₁₂F₆N₂O₂ 
• 1628775-58-5 C₁₅H₁₇F₆NO₂ 

Relevant articles and documents

Copper(II)-Catalysed Aerobic Oxidative Coupling of Arylamines with Hexafluoroisopropanol: An Alternative Methodology for Constructing Fluorinated Compounds

The selective functionalisation of arylamine derivatives with hexafluoroisopropanol through copper(II)-catalysed aerobic oxidative coupling was developed to generate various fluoroalkylated arylamines under mild conditions. This method has a wide substrat

ROR GAMMA (RORY) MODULATORS

The present invention relates to compounds according to Formula I: Wherein: A11 - A14 are N or CR11, CR12, CR13, CR14, respectively, with the proviso that no more than two of the four positions A can be simultaneously N; R1 is C(1-6)alkyl, C(3-6)cycloalkyl, C(3-6)cycloalkylC(1 -3)alkyl, (di)C(1-6)alkylamino, (di)C(3-6)cycloalkylamino or (di)(C(3-6)cycloalkylC(1 -3)alkyl)amino, with all carbon atoms of alkyl groups optionally substituted with one or more F and all carbon atoms of cycloalkyl groups optionally substituted with one or more F or methyl; R2 and R3 are independently H, F, methyl, ethyl, hydroxy, methoxy or R2 and R3 together is carbonyl, all alkyl groups, if present, optionally being substituted with one or more F; R4 is H or C(1-6)alkyl; R5 is H, hydroxyethyl, methoxyethyl, C(1-6)alkyl, C(6-10)aryl, C(6-10)arylC(1-3)alkyl, C(1 -9)heteroaryl, C(1-9)heteroarylC(1-3)alkyl, C(3-6)cycloalkyl, C(3-6)cycloalkylC(1 -3)alkyl, C(2-5)heterocycloalkyl or C(2-5)heterocycloalkylC(1-3)alkyl, all groups optionally substituted with one or more F, CI, C(1-2)alkyl, C(1-2)alkoxy or cyano; the sulfonyl group with R1 is represented by one of R7, R8 or R9; the remaining R6-RH are independently H, halogen, C(1-3)alkoxy, (di)C(1-3)alkylamino or C(1-6)alkyl, all of the alkyl groups optionally being substituted with one or more F; and Ri5 and Ri6 are independently H, C(1-6)alkyl, C(3-6)cycloalkyl, C(3-6)cycloalkylC(1-3)alkyl, C(6-10)aryl, C(6-10)arylC(1-3)alkyl, C(1-9)heteroaryl, C(1-9)heteroarylC(1-3)alkyl, C(2-5)heterocycloalkyl or C(2-5)heterocycloalkylC(1-3)alkyl, all groups optionally substituted with one or more F, CI, C(1-2)alkyl, C(1-2)alkoxy or cyano. The compounds can be used as inhibitors of RORy and are useful for the treatment of RORy mediated diseases.

Discovery and optimization of a novel series of liver X receptor-α agonists

A novel series of hexafluorocarbinols were discovered as potent activators of the liver X receptor-α using a fluorescence polarization assay. Structure-activity relationship study led to the identification of compounds that are more potent agonists than t