14815-86-2

Basic information

• Product Name: 4-(trichloromethyl)benzoyl chloride
• Synonyms: 4-(trichloromethyl)benzoyl chloride
• CAS NO: 14815-86-2
• Molecular Formula: C₈H₄Cl₄O
• Molecular Weight: 257.92876
• EINECS: 238-885-2
• Mol File: 14815-86-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 309.8°Cat760mmHg
• Flash Point: 130.1°C
• Appearance: /
• Density: 1.542g/cm³
• Vapor Pressure: 0.000624mmHg at 25°C
• Refractive Index: 1.578
• CAS DataBase Reference: 4-(trichloromethyl)benzoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(trichloromethyl)benzoyl chloride(14815-86-2)
• EPA Substance Registry System: 4-(trichloromethyl)benzoyl chloride(14815-86-2)

Safety Data

• Hazardous Substances Data: 14815-86-2(Hazardous Substances Data)

Usage

Uses

p-(Trichloromethyl)benzoyl Chloride are used in the synthetic preparation of 4-dichloromethylbenzoyl and 4-trichloromethylbenzoyl chloride as potential antimalaria.

InChI:InChI=1/C8H4Cl4O/c9-7(13)5-1-3-6(4-2-5)8(10,11)12/h1-4H

Upstream product

• 68-36-0 1,4-bis(trichloromethyl)benzene 
• 874-60-2 4-methyl-benzoyl chloride 
• 5264-40-4 4-trichloromethyl-benzoic acid 
• 105-74-8 dilauryl peroxide 
• 99-94-5 p-Toluic acid 

Downstream Products

• 100-21-0 terephthalic acid 
• 5264-40-4 4-trichloromethyl-benzoic acid 
• 81269-26-3 S-(4-acetamidophenyl)-4-trichloromethyl thiolbenzoate 
• 455-24-3 4-trifluoromethylbenzoic acid 
• 709-66-0 para-(trichloromethyl)benzene isocyanate 
• 657-90-9 4-(chloro-difluoro-methyl)-benzoyl fluoride 
• 40069-13-4 4-Trichloromethyl-N-(4-trichloromethyl-benzoyloxy)-benzamide 
• 40069-19-0 N,N'-Bis-(4-trichloromethyl-benzoyloxy)-terephthalamide 
• 40069-05-4 O-Ethyl-4-trichlormethyl-benzohydroxamat 
• 40069-04-3 O-Methyl-n-trichlormethyl-benzohydroxamat 
• 40069-18-9 N-(4-Trichloromethyl-benzoyloxy)-4-trifluoromethyl-benzamide 
• 40212-27-9 N-(4-Trichloromethyl-benzoyloxy)-3-trifluoromethyl-benzamide 
• 63980-12-1 4-trichloromethyl-benzoic acid-(2-chloro-ethyl ester) 
• 100-20-9 terephthaloyl chloride 

Relevant articles and documents

A O-between the - trifluoromethyl benzoic acid to synthetic method (by machine translation)

The present invention provides a O-between the - trifluoromethyl benzoic acid to the synthesis method, the method comprises the following steps: (1) between adjacent to methyl benzoic acid acylated preparation between neighbour methyl benzoyl chloride; (2) between the adjacent methyl benzoyl chloride to chlorine light between neighbour trichloromethyl benzoyl chloride is obtained; (3) adjacent to the trichloromethyl benzoyl chloride fluoride obtained between between neighbour trifluoromethyl methyl benzoyle fluoride; (4) adjacent to the trifluoromethyl benzoyle fluoride hydrolysis between the final product is obtained between neighbour trifluoromethyl methyl benzoic acid. The method of the invention cheap raw material, the product yield is high, the process is simple, is favorable for industrial production. (by machine translation)

Preparation of substituted benzotrichlorides

A process for chlorinating a compound of the formula STR1 in which R1 is a C1 -alkyl radical, C1 -alkoxy radical or C1 -thioalkyl radical, and X1, X2, X3 and X4 are identical or different hydrogen or halogen, and X3 may alternatively be STR2 or --NCO, comprising, in an initial phase, dissolving a chlorination catalyst in the compound to be chlorinated, continuously metering this solution together with chlorine into a reaction vessel containing the compound to be chlorinated, and, after the initial phase, removing partially or fully chlorinated compounds from the reaction vessel, dissolving fresh chlorination catalyst in the removed compounds, and feeding this catalyst solution, together with chlorine, to the reaction vessel.

Preparation and screening of some new thioacetals, sulfones, and derivatives of 4-dichloromethylbenzoyl and 4-trichloromethylbenzoyl chloride as potential antimalarials

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