148278-39-1Relevant articles and documents
Cinchona alkaloid/TiIV-catalyzed enantioselective enaminetrifluoropyruvate condensation-cyclization reaction and its application to drug-like heterocycles
Ogawa, Shinichi,Iida, Norihito,Tokunaga, Etsuko,Shiro, Motoo,Shibata, Norio
supporting information; experimental part, p. 7090 - 7095 (2010/09/16)
(Chemical equation presented) Drug design: A cinchona alkaloid/Ti IVcatalyzed enantioselective tandem enamine-trifluoropyruvate condensation-cyclization reaction provides a robust method for the construction of small heterocyclic molecules with a quaternary trifluoromethylated carbon center (see scheme). The series of products are attractive templates and were readily converted to drug-like trifluoromethylated heterocycles by conventional methods.
