148345-63-5

Basic information

• Product Name: Methyl 3-(5-Tetrazolyl)benzoate
• Synonyms: Methyl 3-(5-Tetrazolyl)benzoate;3-(2H-tetrazol-5-yl)Benzoic acid methyl ester
• CAS NO: 148345-63-5
• Molecular Formula: C₉H₈N₄O₂
• Molecular Weight: 204.18542
• Mol File: 148345-63-5.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Methyl 3-(5-Tetrazolyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-(5-Tetrazolyl)benzoate(148345-63-5)
• EPA Substance Registry System: Methyl 3-(5-Tetrazolyl)benzoate(148345-63-5)

Safety Data

• Hazardous Substances Data: 148345-63-5(Hazardous Substances Data)

Upstream product

• 1129-35-7 4-cyanobenzoic acid methyl ester 
• 1711-11-1 3-cyanobenzoyl chloride 
• 1877-72-1 3-Cyanobenzoic acid 
• 13531-48-1 methyl 3-cyanobenzoate 

Downstream Products

• 136689-94-6 3-(1H-tetrazole-5-yl)benzaldehyde 
• 179056-02-1 3-(1-Methyl-1H-tetrazol-5-yl)-benzaldehyde 
• 179056-01-0 3-(2-methyl-tetrazol-5-yl)-benzaldehyde 
• 179056-45-2 Cycloheptyl-[3-(2-methyl-2H-tetrazol-5-yl)-benzyl]-amine 
• 179056-46-3 Cycloheptyl-[3-(1-methyl-1H-tetrazol-5-yl)-benzyl]-amine 
• 375853-93-3 3-[5-(2-chlorophenyl)-[1,3,4]oxadiazol-2-yl]-benzoic acid methyl ester 
• 73096-39-6 3-(1H-tetrazol-5-yl)benzoic acid 
• 1417905-78-2 C₁₅H₁₂FN₅O 

Relevant articles and documents

Bis(carboxyphenyl)-1,2,4-triazole Based Metal-Organic Frameworks: Impact of Metal Ion Substitution on Adsorption Performance

This work presents the syntheses and comprehensive characterization of six paddlewheel based metal-organic frameworks (MOFs) with the general formula ∞ 3[M2L2] (M = Cu, Co, Zn; L = bis(carboxyphenyl)-1,2,4-triazole) forming an isoreticular series with rutile (rtl) topology. These microporous materials are suitable for a systematic investigation of structure-property relationships based on the impact of the metal ion. Depending on the metal ion, the calculated porosities and the pore diameters reach from 58% to 61% and 300 to 750 pm, respectively. Simultaneous thermal analysis and temperature dependent PXRD studies reveal varying thermal behavior with stabilities up to 400 °C. In the case of syntheses with various Co2+/Cu2+, Co2+/Zn2+, and Cu2+/Zn2+ ratios, ICP-OES analyses and SEM-EDX studies confirm the formation of mixed metal MOFs and the metal ion distribution in the bulk samples as well as within the crystals. For the systematic investigation of CO2 (298 K) and N2 (77 K) adsorption properties, all materials were previously subjected to extraction with supercritical CO2. Depending on the metal ion, this procedure causes different phase transitions for each compound. As a result, adsorption studies reveal varying network flexibility for these MOFs. This study is one of the rare examples demonstrating that targeted modification of gate opening pressure, hysteresis shape, and adsorbed amounts of CO2 or N2 are possible by choice of the metal ion. This finding is supported by adsorption studies on the mixed metal MOF ∞3[(Cu0.48Co0.52)2(p-L)2)], showing CO2 adsorption/desorption characteristics of both homonuclear copper and cobalt materials, whereas N2 does not induce gate opening of the framework, as observed for the cobalt MOF. Furthermore, catalytic studies reveal that ∞ 3[Cu2(p-L)2)] is a suitable catalyst for the oxidation of cyclohexene with tert-butylhydroperoxide (TBHP) with high conversion of the starting materials and good selectivity. Its robustness under the applied catalysis conditions leads to similar conversions in repetition measurements.

CYCLICALLY SUBSTITUTED 3,5-DICYANO-2-THIOPYRIDINES AND USE THEREOF

The present application relates to novel 4-cycloalkyl- and 4-heterocycloalkyl-3,5-dicyano-2-thio-pyridine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of hypertension and other cardiovascular disorders.

Process for the preparation of tetrazoles

The present invention relates to a process for the preparation of 5-aryl tetrazoles of the formula: STR1 or a salt thereof comprising reacting an aryl nitrile with a trisubstituted silyl azide and a disubstituted tin oxide.