148775-24-0

Basic information

• Product Name: 2-Propen-1-ol, 3-(2-chlorophenyl)-, (2E)-
• CAS NO: 148775-24-0
• Molecular Formula: C9H9ClO
• Molecular Weight: 168.623
• Mol File: 148775-24-0.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: 2-Propen-1-ol, 3-(2-chlorophenyl)-, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-ol, 3-(2-chlorophenyl)-, (2E)-(148775-24-0)
• EPA Substance Registry System: 2-Propen-1-ol, 3-(2-chlorophenyl)-, (2E)-(148775-24-0)

Safety Data

• Hazardous Substances Data: 148775-24-0(Hazardous Substances Data)

Upstream product

• 80151-26-4 3-(2-chlorophenyl)-prop-2-yn-1-ol 
• 1794-45-2 (E)-3-(2-chlorophenyl)propenal 
• 89-98-5 2-chloro-benzaldehyde 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 24393-51-9 (E)-ethyl 2-chlorocinnamate 
• 704-96-1 trans-2-chlorocinnamic acid 
• 98288-14-3 methyl (2E)-3-(2-chlorophenyl)prop-2-enoate 

Downstream Products

• 881404-69-9 3-[(E)-3-(2-chlorophenyl)allyl]-3,4-dihydroquinazoline 
• 952682-93-8 (E)-1-chloro-2-(3-chloroprop-1-en-1-yl)benzene 
• 1339110-32-5 (E)-1-(but-1-en-3-yn-1-yl)-2-chlorobenzene 
• 55042-88-1 5-(2-chlorophenyl)-3-methyl-1-phenyl-4,5-dihydro-1H-pyrazole 
• 55068-31-0 5-(2-chlorophenyl)-3-methyl-1-phenyl-1H-pyrazole 
• 1202701-41-4 ((1S,2S,3R)-2-(2-chlorophenyl)-3-iodocyclopropyl)methanol 
• 881404-67-7 (E)-1-(3-bromoprop-1-en-1-yl)-2-chlorobenzene 

Relevant articles and documents

Cinnamaldehydes inhibit cyclin dependent kinase 4/cyclin D1

A series of cinnamaldehydes was synthesized for the study of inhibitory activity against cyclin dependent kinases (CDKs). A couple of compounds selectively inhibited cyclin D1-CDK4 with an IC50 value of 7-18 μM. (C) 2000 Elsevier Science Ltd. All rights reserved.

Selective Synthesis of Z-Cinnamyl Ethers and Cinnamyl Alcohols through Visible Light-Promoted Photocatalytic E to Z Isomerization

A photocatalytic E to Z isomerization of alkenes using an iridium photosensitizer under mild reaction conditions is disclosed. This method provides scalable and efficient access to Z-cinnamyl ether and allylic alcohol derivatives in high yields with excellent stereoselectivity. Importantly, this method also provides a powerful strategy for the selective synthesis of Z-magnolol and honokiol derivatives possessing potential biological activity.

Discovery of novel piperonyl derivatives as diapophytoene desaturase inhibitors for the treatment of methicillin-, vancomycin- and linezolid-resistant Staphylococcus aureus infections

Inhibition of S. aureus diapophytoene desaturase (CrtN) could serve as an alternative approach for addressing the tricky antibiotic resistance by blocking the biosynthesis of carotenoid pigment which shields the bacterium from host oxidant killing. In this study, we designed and synthesized 44 derivatives with piperonyl scaffold targeting CrtN and the structure-activity relationships (SARs) were examined extensively to bring out the discovery of 21b with potent efficacy and better hERG safety profile compared to the first class CrtN inhibitor benzocycloalkane derivative 2. Except the excellent pigment inhibitory activity against wild-type S. aureus, 21b also showed excellent pigment inhibition against four pigmented MRSA strains. In addition, H2O2 killing and human whole blood killing assays proved 21b could sensitize S. aureus to be killed under oxidative stress conditions. Notably, the murine study in vivo validated the efficacy of 21b against pigmented S. aureus Newman, vancomycin-intermediate S. aureus Mu50 and linezolid-resistant S. aureus NRS271.