148965-14-4

Basic information

• Product Name: 3-hydroxy-N-phenyl-5,6,7,8-tetrahydronaphthalene-2-carboxamide
• Synonyms: 3-hydroxy-N-phenyl-5,6,7,8-tetrahydronaphthalene-2-carboxamide
• CAS NO: 148965-14-4
• Molecular Weight: 267.327
• Mol File: 148965-14-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-hydroxy-N-phenyl-5,6,7,8-tetrahydronaphthalene-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-N-phenyl-5,6,7,8-tetrahydronaphthalene-2-carboxamide(148965-14-4)
• EPA Substance Registry System: 3-hydroxy-N-phenyl-5,6,7,8-tetrahydronaphthalene-2-carboxamide(148965-14-4)

Safety Data

• Hazardous Substances Data: 148965-14-4(Hazardous Substances Data)

Upstream product

• 92-77-3 2,3-oxynaphthoic acid phenylamide 
• 90-15-3 α-naphthol 
• 93-12-9 5,6,7,8-tetrahydro-naphthalene-2-sulfonic acid 
• 119-64-2 tetralin 
• 1125-78-6 5,6,7,8-Tetrahydro-2-naphthol 
• 25435-10-3 3-hydroxy-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid 
• 62-53-3 aniline 

Relevant articles and documents

Regioselective and Chemoselective Reduction of Naphthols Using Hydrosilane in Methanol: Synthesis of the 5,6,7,8-Tetrahydronaphthol Core

A regioselective and chemoselective method for catalytic synthesis of biologically interesting 5,6,7,8-tetrahydronaphthols by reduction of naphthols was described. The side aromatic hydrocarbons in naphthols were site-selectively reduced, using hydrosilanes in methanol, allowing for retaining functional phenol scaffolds intact. It presents a rare example of using low-cost and air-stable hydrosilane for catalytic reduction of unactivated aromatic hydrocarbons under mild conditions. This reaction is scalable and proceeds in high selectivity without the formation of 1,2,3,4-tetrahydronaphthol byproducts with toleration of sensitive functionalities such as bromide, chloride, fluoride, ketone, ester, and amide.