14916-79-1 Usage
Description
3-Heptyn-1-ol, also known as 3-heptyn-1-ol, is a colorless liquid with unique chemical properties. It is an organic compound that belongs to the class of alcohols, characterized by the presence of a hydroxyl (-OH) group attached to a carbon atom in its molecular structure. 3-Heptyn-1-ol is particularly known for its role in the preparation and covalent modification of selective COX-2 inactivators, which are crucial in the development of anti-inflammatory and pain-relieving medications.
Uses
Used in Pharmaceutical Industry:
3-Heptyn-1-ol is used as a key intermediate in the synthesis of selective COX-2 inactivators for the pharmaceutical industry. Its unique chemical structure allows for the development of compounds that can effectively target and inhibit the cyclooxygenase-2 (COX-2) enzyme, which is responsible for the production of prostaglandins that cause inflammation and pain. By selectively inhibiting COX-2, these inactivators can provide relief from inflammation and pain without affecting the cyclooxygenase-1 (COX-1) enzyme, which is essential for maintaining the protective lining of the stomach and other normal physiological functions.
Used in Chemical Research:
3-Heptyn-1-ol is also utilized as a valuable research compound in the field of organic chemistry. Its versatile structure makes it an ideal candidate for various chemical reactions and modifications, allowing scientists to explore its potential applications in the development of new drugs, materials, and other chemical products. The compound's reactivity and functional groups can be exploited to synthesize a wide range of derivatives with diverse properties and applications.
Check Digit Verification of cas no
The CAS Registry Mumber 14916-79-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,9,1 and 6 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 14916-79:
(7*1)+(6*4)+(5*9)+(4*1)+(3*6)+(2*7)+(1*9)=121
121 % 10 = 1
So 14916-79-1 is a valid CAS Registry Number.
InChI:InChI=1/C7H12O/c1-2-3-4-5-6-7-8/h8H,2-3,6-7H2,1H3
14916-79-1Relevant articles and documents
A Short Total Synthesis of (+/-)-Gephyrotoxin-223AB
Broka, Chris A.,Eng, Kan K.
, p. 5043 - 5045 (1986)
(+/-)-Gephyrotoxin-223AB has been synthesized from 2-carbomethoxycyclopentanone in nine steps by a route utilizing the stereoselective homolytic cyclization of an alkenyl-substituted N-chloropiperidine.
Tert-Butyl Nitrite Promoted Oxidative Intermolecular Sulfonamination of Alkynes to Synthesize Substituted Sulfonyl Pyrroles from the Alkynylamines and Sulfinic Acids
Qi, Zhenjie,Jiang, Yong,Wang, Yanyan,Yan, Rulong
supporting information, p. 8636 - 8644 (2018/06/18)
tert-Butyl nitrite promoted oxidative intermolecular sulfonamination of alkynes to synthesize substituted sulfonyl pyrroles from the alkynylamines and sulfinic acids via tandem addition/cyclization was developed. This reaction is performed well by employing tert-butyl nitrite as the oxidant, and various substituted sulfonyl pyrroles are formed in moderate to good yields with no requirement of metal catalysis.
A mild method for the deprotection of tetrahydropyranyl (THP) ethers catalyzed by iron(III) tosylate
Bockman, Matthew R.,Angeles, Veronica V.,Martino, Julia M.,Vagadia, Purav P.,Mohan, Ram S.
experimental part, p. 6939 - 6941 (2012/02/05)
A mild method for the deprotection of THP ethers catalyzed by iron(III) tosylate (2.0 mol %) in CH3OH has been developed. Iron(III) tosylate, Fe(OTs)3·6H2O, is a commercially available solid that is inexpensive, noncorrosive, and easy to handle. The room temperature reaction conditions make this method attractive for deprotection of a range of THP ethers.
