1492-15-5

Basic information

• Product Name: AC-VAL-OME
• Synonyms: N-ALPHA-ACETYL-L-VALINE-METHYL ESTER;ACETYL-L-VALINE METHYL ESTER;AC-VAL-OME;AC-VALINE-OME;Ac-L-Val-OMe;N-alpha-Actetyl-L-valine methyl ester;(2S)-2-(Acetylamino)-3-methylbutanoic acid methyl ester;N-Acetylvaline methyl ester
• CAS NO: 1492-15-5
• Molecular Formula: C₈H₁₅NO₃
• Molecular Weight: 173.21
• Product Categories: Amino Acid Derivatives;Amino Acids
• Mol File: 1492-15-5.mol
• Article Data: 48

Chemical Properties

• Melting Point: 61.3-62.5 °C
• Boiling Point: 275.4 °C at 760 mmHg
• Flash Point: 120.4 °C
• Appearance: /
• Density: 1.014 g/cm³
• Storage Temp.: Store at RT.
• PKA: 14.70±0.46(Predicted)
• CAS DataBase Reference: AC-VAL-OME(CAS DataBase Reference)
• NIST Chemistry Reference: AC-VAL-OME(1492-15-5)
• EPA Substance Registry System: AC-VAL-OME(1492-15-5)

Safety Data

• Hazardous Substances Data: 1492-15-5(Hazardous Substances Data)

Usage

General Description

AC-VAL-OME is a chemical compound made up of acetaminophen (AC), codeine phosphate (VAL), and omemazine (OME). Acetaminophen is a commonly used pain reliever and fever reducer, while codeine is a narcotic pain reliever used to treat mild to moderate pain. Omemazine is an antihistamine with sedative properties. Combined, these three chemicals work together to provide pain relief, reduce fever, and may also help to alleviate coughing and other symptoms associated with the common cold or flu. This combination medication is often prescribed for short-term treatment of pain and coughing and should be used with caution due to the potential for codeine to be habit-forming and for acetaminophen to cause liver damage when taken in high doses.

Upstream product

• 52152-47-3 N-acetyl-DL-valine methyl ester 
• 67-56-1 methanol 
• 108-24-7 acetic anhydride 
• 602314-57-8 (4S,5R)-4-hydroxy-3-isopropyl-5-phenyl-4,5-dihydro-isoxazole 
• 4070-48-8 L-valine methyl ester 
• 75-30-9 2-iodo-propane 
• 75-26-3 isopropyl bromide 
• 58561-04-9 N-Boc-valine methyl ester 
• 18424-76-5 dimethyl malonate sodium salt 
• 99166-07-1 (S)-2-Chloro-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazine 
• 6306-52-1 L-valine methylester hydrochloride 
• 39239-85-5 methyl 2-acetamido-3-mercapto-3-methylbutanoate 
• 5619-05-6 DL-valine methyl ester hydrochloride 
• 75-36-5 acetyl chloride 

Downstream Products

• 464-72-2 tetraphenylethane-1,2-diol 
• 72-18-4 L-valine 
• 132903-67-4 Arg-Lys-Asp-Val-Tyr tris trifluoroacetate 
• 37933-88-3 N-acetyl-L-valinamide 
• 17916-88-0 N-acetyl-D-valine 
• 96-81-1 N-acetyl-L-valine 
• 19701-84-9 N-Ac-Val-NHMe 

Relevant articles and documents

A Mild, General, Metal-Free Method for Desulfurization of Thiols and Disulfides Induced by Visible-Light

A visible-light-induced metal-free desulfurization method for thiols and disulfides has been explored. This radical desulfurization features mild conditions, robustness, and excellent functionality compatibility. It was successfully applied not only to the desulfurization of small molecules, but also to peptides.

Oxidative Damage in Aliphatic Amino Acids and Di- and Tripeptides by the Environmental Free Radical Oxidant NO3?: the Role of the Amide Bond Revealed by Kinetic and Computational Studies

Kinetic and computational data reveal a complex behavior of the important environmental free radical oxidant NO3? in its reactions with aliphatic amino acids and di- and tripeptides, suggesting that attack at the amide N-H bond in the peptide backbone is a highly viable pathway, which proceeds through a proton-coupled electron transfer (PCET) mechanism with a rate coefficient of about 1 × 106 M-1 s-1 in acetonitrile. Similar rate coefficients were determined for hydrogen abstraction from the α-carbon and from tertiary C-H bonds in the side chain. The obtained rate coefficients for the reaction of NO3? with aliphatic di- and tripeptides suggest that attack occurs at all of these sites in each individual amino acid residue, which makes aliphatic peptide sequences highly vulnerable to NO3?-induced oxidative damage. No evidence for amide neighboring group effects, which have previously been found to facilitate radical-induced side-chain damage in phenylalanine, was found for the reaction of NO3? with side chains in aliphatic peptides.

Simple and efficient Fmoc removal in ionic liquid

A mild method for an efficient removal of the fluorenylmethoxycarbonyl (Fmoc) group in ionic liquid was developed. The combination of a weak base such as triethylamine and [Bmim][BF4] makes the entire system more efficient for the cleavage at room temperature of various amines and amino acid methyl esters in short reaction times. The procedure works well even in the case of N-Fmoc amino acids bearing acid-sensitive protecting groups and of N-alkylated amino acid methyl esters. The solvent-free condition provides a complementary method for Fmoc deprotection in solution phase peptide synthesis and modern organic synthesis.