149602-63-1

Basic information

• Product Name: 2-(tert-butoxycarbonyl)propyl methanesulfonate
• Synonyms: 2-(tert-butoxycarbonyl)propyl methanesulfonate
• CAS NO: 149602-63-1
• Molecular Weight: 253.32
• Mol File: 149602-63-1.mol
• Article Data: 49

Chemical Properties

• CAS DataBase Reference: 2-(tert-butoxycarbonyl)propyl methanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(tert-butoxycarbonyl)propyl methanesulfonate(149602-63-1)
• EPA Substance Registry System: 2-(tert-butoxycarbonyl)propyl methanesulfonate(149602-63-1)

Safety Data

• Hazardous Substances Data: 149602-63-1(Hazardous Substances Data)

Usage

Structure

A propyl group attached to a methanesulfonate group and a tert-butoxycarbonyl (Boc) protecting group

Common uses

As a reagent in organic synthesis, particularly in the protection of amines and amino acids

Functionality

The Boc protecting group helps to prevent unwanted reactions from occurring in specific functional groups, allowing for selective manipulation of the molecule

Reactivity

Highly reactive

Handling

Should be handled with care in a controlled laboratory environment

Upstream product

• 3744-87-4 Boc-(R)-Ala 
• 129991-09-9 (R)-N-Boc-2-aminobutane 
• 124-63-0 methanesulfonyl chloride 
• 79069-13-9 (R)-2-tertbutoxycarbonylamino-1-propanol 
• 91103-47-8 N-(tert-butoxycarbonyl)-D-alanine methyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1220498-82-7 (2'''R)-1'-(2'''-tert-butoxycarbonylaminopropoxy)-4'-(2'',6''-dimethoxyphenyl)-1,2'-binaphthyl-8-carbonitrile 
• 1297539-77-5 (R)-tert-butyl 1-(3-(3-chloro-4-cyano-2-methylphenyl)-1H-pyrazol-1-yl)propan-2-ylcarbamate 
• 100927-10-4 tert-butyl N-[(1R)-2-amino-1-methyl-ethyl]carbamate 
• 170367-68-7 (2-cyano-1(R)-methylethyl)carbamic acid, 1,1-dimethylethyl ester 
• 1204483-89-5 tert-butyl {2-[4-(4-benzyloxyphenoxy)phenoxy]-1-methylethyl}carbamate 
• 101507-03-3 ((E)-(R)-1-Methyl-3-phenyl-allyl)-carbamic acid tert-butyl ester 
• 170367-78-9 [4-[[3-[[(1,1-dimethylethoxy)carbonyl]amino]butyl](phenylmethyl)amino]butyl]carbamic acid, 11-[[(1,1-dimethylethoxy)carbonyl]amino]-15,15-dimethyl-2,13-dioxo-14-oxa-3,4,12-triaza-11-hexadecen-1-yl ester (R) 
• 170367-82-5 [21-[[(1,1-dimethylethoxy)carbonyl]amino]-1,25,25-trimethyl-10,12,23-trioxo-4-(phenylmethyl)-24-oxa-4,9,13,20,22-pentaaza-21-hexacosen-1-yl]carbamic acid, 1,1-dimethylethyl ester (R) 
• 170367-76-7 2,2,6-trimethyl-4,15-dioxo-9-(phenylmethyl)-3,16-dioxa-5,9,14-triazaoxadecan-18-oic acid (R) 
• 252353-69-8 [3-[[4-(2,4-dioxo-3-oxazolidinyl)butyl](phynylmethyl)amino]-1-methylpropyl]carbamic acid, 1,1-dimethylethyl ester (R) 
• 170367-72-3 3-[(4-aminobutyl)(phenylmethyl)amino-1(R)-methylpropyl]carbamic acid, 1,1-dimethylethyl ester 
• 170367-71-2 3-[(3-cyanopropyl)(phenylmethyl)amino-1(R)-methylpropyl]carbamic acid, 1,1-dimethylethyl ester 
• 170367-70-1 [1(R)-methyl-3-[(phenylmethyl)amino]propyl]carbamic acid, 1,1-dimethylethyl ester 

Relevant articles and documents

Evaluation of 5-(Trifluoromethyl)-1,2,4-oxadiazole-Based Class IIa HDAC Inhibitors for Huntington's Disease

Using an iterative structure-activity relationship driven approach, we identified a CNS-penetrant 5-(trifluoromethyl)-1,2,4-oxadiazole (TFMO, 12) with a pharmacokinetic profile suitable for probing class IIa histone deacetylase (HDAC) inhibition in vivo.

HETEROCYCLIC COMPOUNDS

Provided herein are compounds of formula (I) which comprise a thiomorpholine 1,1-dioxide or 1-imino-thiomorpholine 1-oxide moiety, or pharmaceutically acceptable salts of any of the foregoing, pharmaceutical compositions that include a compound described herein (including salts of the compound) and methods of synthesizing the same. Also provided are methods of treating Hepatitis B viral (HBV) infections using a compound of formula (I), or pharmaceutically acceptable salts thereof.

SULFUR-CONTAINING POLYCYCLIC-HYDROXYPYRIDONE CARBOXAMIDE ANALOG AGAINST HIV

The disclosure discloses a sulfur-containing polycyclic-hydroxypyridone carboxamide analog against HIV and an application thereof. The sulfur-containing polycyclic-hydroxypyridone carboxamide analog has a compound represented by the following formula (I)