149849-92-3

Basic information

• Product Name: 1-(5-TRIFLUOROMETHYL-[1,3,4]THIADIAZOL-2-YL)-PIPERAZINE
• Synonyms: CHEMBRDG-BB 4010944;AKOS BBS-00002507;2-Chloropyrimidine-4-carboxylic acid;4-Pyrimidinecarboxylic acid, 2-chloro-;4-Carboxy-2-chloropyrimidine;4-Carboxy-2-chloropyrimidine, 4-Carboxy-2-chloro-1,3-diazine;2-Chloro-pyrimidin-4-carboxylic acid
• CAS NO: 149849-92-3
• Molecular Formula: C₅H₃ClN₂O₂
• Molecular Weight: 158.54
• Product Categories: pharmacetical;pyrimidine;Building Blocks;Heterocycle-Pyrimidine series
• Mol File: 149849-92-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 411.407 °C at 760 mmHg
• Flash Point: 202.612 °C
• Appearance: /
• Density: 1.579
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.598
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 2.44±0.10(Predicted)
• CAS DataBase Reference: 1-(5-TRIFLUOROMETHYL-[1,3,4]THIADIAZOL-2-YL)-PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-TRIFLUOROMETHYL-[1,3,4]THIADIAZOL-2-YL)-PIPERAZINE(149849-92-3)
• EPA Substance Registry System: 1-(5-TRIFLUOROMETHYL-[1,3,4]THIADIAZOL-2-YL)-PIPERAZINE(149849-92-3)

Safety Data

• Statements: 36/37/38
• Safety Statements: 22-26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 149849-92-3(Hazardous Substances Data)

Usage

Chemical Properties

Yellow to light brown or brown solid

InChI:InChI=1/C5H3ClN2O2/c6-5-7-2-1-3(8-5)4(9)10/h1-2H,(H,9,10)

Upstream product

• 149849-93-4 2-chloropyrimidine-4-carboxylic acid chloride 
• 75833-38-4 2-chloro-pyrimidine-4-carbonitrile 
• 13036-57-2 2-chloro-4-methylpyrimidine 

Downstream Products

• 1351933-87-3 2-(4-(benzyloxy)phenyl)pyrimidine-4-carboxylic acid 

Relevant articles and documents

Synthesis method of 2-chloropyrimidine-4-formic acid

The invention relates to a synthesis method of 2-chloropyrimidine-4-formic acid. 2, 4-dichloropyrimidine is used as a starting raw material, the target product 2-chloropyrimidine-4-formic acid is prepared through a two-step reaction, and the whole synthesis process is high in yield, the purity is good, and the operation is convenient, green and environmentally friendly, therefore the method is suitable for industrial production.

Method for preparing 2-chloropyrimidine-4 formic acid

The invention relates to a method for preparing 2-chloropyrimidine-4 formic acid. The method comprises the following steps: performing debydrochlorination reaction on 2-chlorine-4-methyl pyridine hydrochloride and phosphorus oxychloride and separating, thereby acquiring 2-chlorine-4-methyl pyridine; and performing methyl oxidizing reaction on 2-chlorine-4-methyl pyridine and methyl oxidant and separating, thereby acquiring 2-chloropyrimidine-4 formic acid. According to the process route provided by the invention, the yield of the target product is high, the process route can be amplified, the raw materials can be easily acquired and have low cost, and industrial production can be carried out.