14994-81-1

Basic information

• Product Name: m-aminophenyl azide
• Synonyms: m-aminophenyl azide
• CAS NO: 14994-81-1
• Molecular Weight: 134.14
• Mol File: 14994-81-1.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: m-aminophenyl azide(CAS DataBase Reference)
• NIST Chemistry Reference: m-aminophenyl azide(14994-81-1)
• EPA Substance Registry System: m-aminophenyl azide(14994-81-1)

Safety Data

• Hazardous Substances Data: 14994-81-1(Hazardous Substances Data)

Upstream product

• 1516-59-2 3-nitrophenyl azide 
• 591-19-5 m-Bromoaniline 
• 110-70-3 N,N`-dimethylethylenediamine 
• 30418-59-8 3-Aminophenylboronic acid 
• 101-09-7 (3-amino-phenyl)-oxalamic acid 
• 621-35-2 N-(3-aminophenyl)-acetamide hydrochloride 

Downstream Products

• 115073-33-1 3-azido-N-(4-chlorobutanoyl)aniline 
• 1158814-65-3 8-[1-(3-aminophenyl)-1H-1,2,3-triazol-4-yl]-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)adenosine 
• 1422965-70-5 ethyl 1-(3-aminophenyl)-5-(trifluoromethyl)-1H-1,2,3-triazole-4-carboxylate 
• 1422965-75-0 ethyl 1-(3-aminophenyl)-5-(difluoromethyl)-1H-1,2,3-triazole-4-carboxylate 

Relevant articles and documents

Cycloaddition of: N -sulfonyl and N -sulfamoyl azides with alkynes in aqueous media for the selective synthesis of 1,2,3-triazoles

The cycloaddition of N-sulfonyl and N-sulfamoyl azides with terminal alkynes generally produces amide derivatives via ketenimine intermediates. We herein delineate a Cu(i) catalyzed method using a prolinamide ligand that selectively generates N-sulfonyl a

PYRIDINYL BASED APOPTOSIS SIGNAL-REGULATION KINASE INHIBITORS

Apoptosis signal-regulating kinase 1 (ASK1) activation and signaling have been reported to play an important role in a broad range of diseases including neurodegenerative, cardiovascular, inflammatory, autoimmunity and metabolic disorders. Disclosed herein is the synthesis of pyridinyl derived therapeutic agents that function as inhibitors of ASK 1 as well as their pharmaceutical compositions and methods of use.

Selective recognition of: C-MYC G-quadruplex DNA using prolinamide derivatives

Herein we report the design, synthesis, biophysical and biological evaluation of triazole containing prolinamide derivatives as selective c-MYC G-quadruplex binding ligands. A modular synthetic route has been devised for prolinamide derivatives using a copper(i) catalyzed azide-alkyne cycloaddition (CuAAC). The F?rster resonance energy transfer (FRET) melting assay indicates that prolinamide trimers can significantly stabilize G-quadruplex structures over duplex DNA compared to prolinamide dimers. The fluorescent intercalator displacement (FID) assay shows that a trimer with prolinamide side chains at the para-position of the benzene ring can discriminate between different quadruplex structures and exhibits the highest binding affinity towards the c-MYC G-quadruplex structure. Molecular modeling studies reveal that the prolinamide trimer stacks upon the terminal G-quartet of the c-MYC G-quadruplex. Atomic force microscopy (AFM) analysis reveals that the tris-prolinamide ligand can be used to regulate the assembly of novel supramolecular nanoarchitectures. Further, in vitro cellular studies with human hepatocellular carcinoma (HepG2) cells indicate that the tris-prolinamide derivatives can inhibit cell proliferation and reduce c-MYC expression in cancer cells.