150036-88-7 Usage
Description
Verongamine is a monocarboxylic acid amide derivative, specifically N-[2-(1H-imidazol-4-yl)ethyl]propanamide, which is substituted by a hydroxyimino group at position 2 and a 3-bromo-4-methoxyphenyl group at position 3. It is a bromotyrosine derivative isolated from the marine sponge Verongula gigantea and is known for its histamine-H3 antagonist activity.
Uses
Used in Pharmaceutical Industry:
Verongamine is used as a histamine-H3 antagonist for its ability to block the histamine-H3 receptors, which play a role in various physiological processes, including the regulation of wakefulness, appetite, and cognitive functions. This application is particularly relevant in the development of drugs targeting conditions such as insomnia, attention deficit hyperactivity disorder (ADHD), and Alzheimer's disease.
Used in Marine Biotechnology:
In the field of marine biotechnology, verongamine is used as a source of bioactive compounds derived from marine organisms. Its unique chemical structure and biological activity make it a valuable candidate for further research and potential development of new therapeutic agents.
Used in Chemical Research:
Verongamine is also used as a research tool in chemical research, particularly in the study of natural products and their interactions with biological systems. Its histamine-H3 antagonist activity provides insights into the structure-activity relationships of related compounds and can aid in the design of novel drugs with improved pharmacological properties.
Check Digit Verification of cas no
The CAS Registry Mumber 150036-88-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,0,0,3 and 6 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 150036-88:
(8*1)+(7*5)+(6*0)+(5*0)+(4*3)+(3*6)+(2*8)+(1*8)=97
97 % 10 = 7
So 150036-88-7 is a valid CAS Registry Number.
InChI:InChI=1/C15H17BrN4O3/c1-23-14-3-2-10(6-12(14)16)7-13(20-22)15(21)18-5-4-11-8-17-9-19-11/h2-3,6,8-9,22H,4-5,7H2,1H3,(H,17,19)(H,18,21)/b20-13+
150036-88-7Relevant articles and documents
Approaches to the synthesis of some tyrosine-derived marine sponge metabolites: Synthesis of verongamine and purealidin N
Boehlow,Harburn,Spilling
, p. 3111 - 3118 (2007/10/03)
The oxidation of tyrosine ethyl ester (7) with Na2WO4/H2O2 in ethanol, dimethyldioxirane in acetone, or methyltrioxorhenium/H2O2 in EtOH gave the corresponding tyrosine oxime (8) in high yi
