1506-53-2Relevant articles and documents
Reactivity of secondary N-alkyl acrylamides in Morita–Baylis–Hillman reactions
Ahmar, Mohammed,Queneau, Yves,Verrier, Charlie,Yue, Xiaoyang
, p. 319 - 330 (2021/10/29)
The Morita–Baylis–Hillman (MBH) reaction of secondary N-alkyl acrylamides, discarded up to now from investigations of the scope of activated alkenes, was studied. Optimization of the reaction conditions revealed that a balance must be found between activation of the MBH coupling reaction and that of the undesired competitive aldehyde Cannizzaro reaction. Using 3-Hydroxyquinuclidine (3-HQD) in a 1:1 water-2-MeTHF mixture provides the appropriate conditions that were applicable to a wide range of diversely substituted secondary N-alkyl acrylamides and aromatic aldehydes, giving rise to novel amide-containing MBH adducts under mild and clean conditions.
Direct Deuteration of Acrylic and Methacrylic Acid Derivatives Catalyzed by Platinum on Carbon in Deuterium Oxide
Park, Kwihwan,Matsuda, Takumi,Yamada, Tsuyoshi,Monguchi, Yasunari,Sawama, Yuka,Doi, Naoki,Sasai, Yasushi,Kondo, Shin-Ichi,Sawama, Yoshinari,Sajiki, Hironao
supporting information, p. 2303 - 2307 (2018/05/07)
The platinum on carbon (Pt/C)-catalyzed deuteration of acrylic and methacrylic acid derivatives in deuterium oxide (D2O) efficiently proceeded to give the corresponding acrylic acid-d3 and methacrylic acid-d5 derivatives. The olefinic functionality, as well as the methyl group on the unsaturated functionality of the substrate, were satisfactorily deuterated via the hydrogen (H)-deuterium (D) exchange reaction. The obtained deuterated compounds are useful building blocks and efficiently converted to the corresponding desired products including a polymer without the degradation of the original deuterium contents. (Figure presented.).
N-alkyl acrylamide intermediate and preparation method thereof and preparation method of N-alkyl acrylamide
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Paragraph 0153; 0156; 0157; 0158, (2017/01/26)
The invention belongs to the field of acrylamide, and particularly relates to an N-alkyl acrylamide intermediate and a preparation method thereof and a preparation method of N-alkyl acrylamide.The preparation method of N-alkyl acrylamide comprises the following steps that a cracking reaction is conducted on a compound with the structure of a formula (I) in the presence of a cracking catalyst, and N-alkyl acrylamide with the structure of a formula (VII) is obtained, wherein R1 and R2 are independently selected from alkyl, and n is larger than or equal to 0 and smaller than or equal to 30.The yield of N-alkyl acrylamide prepared through the method is high.It is indicated through experimental results that the total yield of N-alkyl acrylamide prepared through the method is larger than 85%.Please see the formulas in the description.