151-73-5 Usage
Indications and Usage
Betamethasone Sodium Phosphate, also called Bentelan, Betnesol, betamethasone phosphate, and celestone phosphate, is an adrenal cortex hormone, an isomer of dexamethasone with the same effects as prednisolone and dexamethasone.
It is mainly used against inflammation and allergies. Its effects are the same as those of dexamethasone, and its anti-inflammatory effects are stronger than dexamethasone, prednisone, and cortisone, with fewer side effects. It is used to treat active rheumatism, rheumatoid arthritis, lupus erythematosus, severe bronchial asthma, severe dermatitis, acute leukemia, allergic dermatitis, eczema, neurodermatitis, seborrheic dermatitis, pruritis, and comprehensively treat some infections.
Mechanisms of Action
Betamethasone sodium phosphate has pharmacological effects in treating inflammation, rheumatism, allergies, and immunosuppressive conditions. Its anti-inflammatory effects are stronger than those of dexamethasone, triamcinolone, and hydrocortisone. It can reduce and prevent tissue response to inflammation, partly eliminating non-infectious inflammation caused by fever, redness, and swelling, thereby reducing the presence of swelling. The anti-inflammatory effects of 0.3 mg of betamethasone sodium phosphate are comparable to those of 0.75 mg of dexamethasone, 5 mg of prednisone, or 25 mg of cortisone. Its sodium retention effects are more than a hundred times those of cortisone. In case of primary adrenal hypofunction, together with corticosteroids, it can be used to replace treatment or prevention, or inhibit of cellular immune response, delay allergic reaction, and reduce the extension of the primary immune response, suitable for low renin and low aldosterone syndrome and orthodontic hypotension caused by autonomic neuropathy.
Contraindications
Not for use by those with a history of serious mental illness, active duodenum, gastric ulcers, recent gastrointestinal anastomosis, serious osteoporosis, pronounced diabetes, or serious high blood pressure, viruses which cannot be treated by antibiotics, bacterial of fungal infection, thrombophlebitis, or infectious skin diseases such as impetigo, tinea corporis, or tinea cruris.
Category
Toxic
Toxicity level
Medium
Acute toxicity
Oral administration - mice LD50: >4500 mg/kg
Flammability
Flammable; produces toxic fluoride fumes
Storage and transport
Store in a cool, ventilated, and dry place
Extinguishing agents
Dry powder, foam, sand, carbon dioxide, mist
Chemical Properties
White or almost white powder, very hygroscopic.
Uses
Different sources of media describe the Uses of 151-73-5 differently. You can refer to the following data:
1. An anti-inflammatory agent
2. A Betamethasone
3. antiinflammatory, glucocorticoid
4. Nasal, Ophthalmic, Oral, Parenteral
5. Betamethasone 21-Phosphate Disodium Salt (Dexamethasone Sodium Phosphate EP Impurity B) is a Betamethasone derivative. It is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties which can be used in treatment of asthma and itching.
Definition
ChEBI: An organic sodium salt that is the disodium salt of betamethasone phosphate.
Brand name
Celestone (Schering).
Biochem/physiol Actions
Betamethasone is used to treat neonatal respiratory distress syndrome, and psoriasis.
Safety Profile
Moderately toxic by ingestion andother routes. An experimental teratogen. Otherexperimental reproductive effects. When heated todecomposition it emits toxic fumes of F??, POx and Na2O.
Check Digit Verification of cas no
The CAS Registry Mumber 151-73-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,5 and 1 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 151-73:
(5*1)+(4*5)+(3*1)+(2*7)+(1*3)=45
45 % 10 = 5
So 151-73-5 is a valid CAS Registry Number.
