151133-14-1

Basic information

• Product Name: Carbamic acid, [(1S)-1-[(4-hydroxyphenyl)methyl]-2-(methoxymethylamino)-2-oxoethyl]-, 1,1-dimethylethyl ester
• CAS NO: 151133-14-1
• Molecular Formula: C16H24N2O5
• Molecular Weight: 324.377
• Mol File: 151133-14-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(1S)-1-[(4-hydroxyphenyl)methyl]-2-(methoxymethylamino)-2-oxoethyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1S)-1-[(4-hydroxyphenyl)methyl]-2-(methoxymethylamino)-2-oxoethyl]-, 1,1-dimethylethyl ester(151133-14-1)
• EPA Substance Registry System: Carbamic acid, [(1S)-1-[(4-hydroxyphenyl)methyl]-2-(methoxymethylamino)-2-oxoethyl]-, 1,1-dimethylethyl ester(151133-14-1)

Safety Data

• Hazardous Substances Data: 151133-14-1(Hazardous Substances Data)

Upstream product

• 3978-80-1 Boc-Tyr-OH 
• 1117-97-1 N,0-dimethylhydroxylamine 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 94732-15-7 (S)-2-(2-N-tert-butoxycarbonylamino)-3-[4-(tert-butyldimethylsilyloxy)phenyl]-propanoic acid 
• 2942-58-7 diethyl cyanophosphonate 

Downstream Products

• 949910-02-5 (S)-2-Amino-N-[(S)-2-ethylcarbamoyl-2-hydroxy-1-(4-hydroxy-benzyl)-ethyl]-3-methyl-butyramide 
• 949910-38-7 5-[1,2]Dithiolan-3-yl-pentanoic acid {(S)-1-[(S)-2-ethylcarbamoyl-2-hydroxy-1-(4-hydroxy-benzyl)-ethylcarbamoyl]-2-methyl-propyl}-amide 
• 210428-06-1 {(S)-2-[4-(tert-Butyl-diphenyl-silanyloxy)-phenyl]-1-formyl-ethyl}-carbamic acid tert-butyl ester 
• 1262483-06-6 C₃₂H₄₂N₂O₅Si 
• 170096-21-6 tert-butyl(S)-2-[4-(2-methoxy-ethoxy)-phenyl]-1-(methoxy-methyl-carbamoyl)-ethylcarbamate 
• 1026274-05-4 [(E)-(S)-3-Benzenesulfonyl-1-(4-hydroxy-benzyl)-allyl]-carbamic acid tert-butyl ester 
• 420118-95-2 4-tert-butoxycarbonylamino-5-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-pent-2-enoic acid methyl ester 
• 420118-96-3 (E)-(S)-4-Amino-5-(4-hydroxy-phenyl)-pent-2-enoic acid methyl ester 
• 149451-90-1 {(S)-2-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-1-formyl-ethyl}-carbamic acid tert-butyl ester 
• 420118-94-1 [2-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-1-(methoxy-methyl-carbamoyl)-ethyl]-carbamic acid tert-butyl ester 
• 134081-15-5 N-(tert-butyloxycarbonyl)-L-tyrosinal 
• 151133-11-8 [(S)-1-(Methoxy-methyl-carbamoyl)-2-(4-triisopropylsilanyloxy-phenyl)-ethyl]-carbamic acid tert-butyl ester 
• 151133-12-9 (E)-(S)-4-tert-Butoxycarbonylamino-5-(4-triisopropylsilanyloxy-phenyl)-pent-2-enoic acid 
• 151133-13-0 [(S)-1-Formyl-2-(4-triisopropylsilanyloxy-phenyl)-ethyl]-carbamic acid tert-butyl ester 

Relevant articles and documents

An expedient conversion of α-amino acids into Weinreb amides using COMU As a coupling agent

The use of COMU, as a non-hazardous partner, in the coupling of N-protected α-amino acids to N-methoxy-N-methylamine to afford the corresponding Weinreb amides is discussed. From a practical point of view the reaction can be monitored visually by virtue of the colour change associated with the conversion of substrates (yellow) into the products (orange). As the by-products of the reaction are conveniently water-soluble the products are isolated relatively pure and with minimal racemisation. These factors coupled with the short reaction time make this a very useful procedure.

Novel cell-penetrating α-keto-amide calpain inhibitors as potential treatment for muscular dystrophy

Dipeptide-derived α-keto-amide compounds with potent calpain inhibitory activity have been identified. These reversible covalent inhibitors have IC50 values down to 25 nM and exhibit greatly improved activity in muscle cells compared to the reference compound MDL28170. Several novel calpain inhibitors have shown positive effects on histological parameters in an animal model of Duchenne muscular dystrophy demonstrating their potential as a treatment option for this fatal disease.

Vinyl Sulfones as Mechanism-Based Cysteine Protease Inhibitors

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