151378-64-2Relevant articles and documents
Kinetics and Mechanism of syn-Elimination of Ammonia from (2S,3R)-3-Methylaspartic Acid by Methylaspartase
Archer, Catherine H.,Gani, David
, p. 140 - 142 (1993)
Methylaspartase catalyses the slow syn-elimination of ammonia from the (2S,3R)--diastereoisomer of the natural substrate (2S,3S)-3-methylaspartic acid, to give mesaconic acid; the reaction does not involve C-3 epimerisation followed by normal anti-elimination, ruling-out the possibility of a carbanion intermediate, but, displays large primary deuterium isotope effects consistent with concerted C-H and C-N bond cleavage.
