1515-84-0

Basic information

• Product Name: 1-(MethoxyMethyl)-3-nitrobenzene
• Synonyms: 1-(MethoxyMethyl)-3-nitrobenzene
• CAS NO: 1515-84-0
• Molecular Formula: C₈H₉NO₃
• Molecular Weight: 167.16196
• Mol File: 1515-84-0.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(MethoxyMethyl)-3-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(MethoxyMethyl)-3-nitrobenzene(1515-84-0)
• EPA Substance Registry System: 1-(MethoxyMethyl)-3-nitrobenzene(1515-84-0)

Safety Data

• Hazardous Substances Data: 1515-84-0(Hazardous Substances Data)

Usage

General Description

1-(MethoxyMethyl)-3-nitrobenzene, also known as 3-Nitrobenzyl methyl ether, is a chemical compound with the molecular formula C8H9NO3. It is a pale yellow crystalline solid with a molecular weight of 167.16 g/mol. 1-(MethoxyMethyl)-3-nitrobenzene is commonly used in organic synthesis as a reagent for the methylation of various compounds. It is also a key intermediate in the production of pharmaceuticals, agrochemicals, and other fine chemicals. Additionally, 1-(MethoxyMethyl)-3-nitrobenzene has been studied for its potential use in the development of new materials and as a building block for the synthesis of diverse organic compounds. Its chemical properties make it a versatile and valuable compound in the field of chemistry.

Upstream product

• 619-25-0 3-Nitrobenzyl alcohol 
• 77-78-1 dimethyl sulfate 
• 538-86-3 benzyl methyl ether 
• 619-23-8 3-Nitrobenzyl chloride 
• 124-41-4 sodium methylate 
• 3958-57-4 1-bromomethyl-3-nitrobenzene 
• 74-88-4 methyl iodide 
• 868-85-9 Dimethyl phosphite 
• 74-83-9 methyl bromide 
• 67-56-1 methanol 

Downstream Products

• 99-61-6 3-nitro-benzaldehyde 
• 618-95-1 methyl 3-nitrobenzoate 
• 98405-93-7 α-hydroperoxy-m-nitrobenzyl methyl ether 
• 1260095-69-9 4-tert-butyl-1-(3-(3,4-dihydroxybenzamido)benzyl)pyridinium bromide 
• 1260095-65-5 N-(3-bromomethylphenyl)-3,4-dihydroxybenzamide 
• 1260095-61-1 N-(3-methoxymethylphenyl)-2,2-diphenylbenzo[d][1,3]dioxole-5-carboxamide 
• 53473-83-9 3-(1-methoxymethyl)phenylamine 

Relevant articles and documents

Liquid crystal aligning agent for photoalignment, liquid crystal alignment film and liquid crystal display device using it, and diamine and polymer

Provided are a liquid crystal alignment film capable of being given anisotropy through photoalignment and stable to light, and a liquid crystal display device capable of keeping a high voltage holding ratio without degradation of display quality even when

N-Phenyl-N′-(2-chloroethyl)ureas (CEU) as potential antineoplastic agents. Part 2: Role of ω-hydroxyl group in the covalent binding to β-tubulin

Tubulin is the target of many anticancer drugs, including N-phenyl-N′-(2-chloroethyl)urea (CEU). Unlike most anti-β-tubulin agents, CEUs are protein monoalkylating agents binding through their N′-(2-chloroethyl)urea moiety to an amino acid nearby the colchicine-binding site on β-tubulin isoform-2. Following the previously synthesized and attractive N-(3-ω-hydroxyalkylphenyl)-N′-(2-chloroethyl)urea that exhibited growth inhibitory activity at the nanomolar level, we investigated the importance of lower alkyl and alkoxy groups to evaluate the effect of hydroxylated group and chain length on both cell growth inhibition and the mechanism of action of CEU. Here, we describe the preparation of two new series of CEU and show that the most potent CEU derivatives beside the ω-hydroxylated 1f were 2f and 3e, respectively. We have confirmed that the pentyl substituted CEUs 1f, 2f, and 3e are still covalently binding to β-tubulin and still arrest cell division in G2/M phase. Crown Copyright

REACTIVITY OF THE ACIDS OF TRIVALENT PHOSPHORUS AND THEIR DERIVATIVES. PART IV. THE REACTION OF DIALKYLPHOSPHITE ANIONS WITH NITROBENZYL BROMIDES

The reaction of o-, m- and p-nitrobenzyl bromide with sodium dimethylphosphite as well as sodium diisopropylphosphite in THF and alcohols as the solvent is described.According to the constitution of the starting materials and the solvents used, the formation of the P-C bond, debromination or dimerization occurs.The principal process in o- and p-nitrobenzyl bromide and >P-O- anion systems is believed to be X-philic substitution, the dimer is formed through a secondary process via SET from the nitrobenzyl anion to nitrobenzyl bromide.Electron-transfer and proton-transfer processes in the nitrobenzyl bromide->P-O- systems are also discussed.Key words: o-, m- and p-nitrobenzyl bromides, dialkyl phosphites, Michaelis-Becker reaction, X-philic substitution, SET.