1516898-91-1

Basic information

• Product Name: 2-phenyl-3-((trifluoromethyl)thio)-1H-indole
• Synonyms: 2-phenyl-3-((trifluoromethyl)thio)-1H-indole
• CAS NO: 1516898-91-1
• Molecular Weight: 293.312
• Mol File: 1516898-91-1.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: 2-phenyl-3-((trifluoromethyl)thio)-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-3-((trifluoromethyl)thio)-1H-indole(1516898-91-1)
• EPA Substance Registry System: 2-phenyl-3-((trifluoromethyl)thio)-1H-indole(1516898-91-1)

Safety Data

• Hazardous Substances Data: 1516898-91-1(Hazardous Substances Data)

Upstream product

• 1045821-71-3 N-[(trifluoromethyl)sulfanyl]aniline 
• 13141-38-3 2-phenylethynylaniline 
• 811-68-7 silver(I) trifluoromethanethiolate 
• 199277-23-1 1-azido-2-(phenylethynyl)benzene 
• 98-80-6 phenylboronic acid 
• 120-72-9 indole 
• 948-65-2 2-phenyl-indole 
• 719-98-2 N-((trifluoromethyl)thio)isoindoline-1,3-dione 
• 421-83-0 trifluoromethane sulfonyl chloride 
• 56572-25-9 2-(trifluoromethylsulfonyl)-N-tert-butoxycarbonylhydrazine 
• 2926-29-6 Langlois reagent 

Relevant articles and documents

POCl3-Promoted Trifluoromethylthiolation-Based Vicinal Bifunctionalization of Indoles with CF3SO2Na

An efficient trifluoromethylthiolation-based vicinal bifunctionalization of indoles with sodium trifluoromethanesulfinate in the presence of phosphorus oxychloride were achieved to introduce a chlorine atom into the 2-position under transition-metal-free

Synthesis of 3-((trifluoromethyl)thio)indoles via trifluoromethylthiolation of 2-alkynyl azidoarenes with AgSCF3

Direct and effective trifluoromethylthiolation of 2-alkynyl azidoarenes with silver(I) trifluoromethanethiolate (AgSCF3) has been developed for the construction of 3-((trifluoromethyl)thio)indoles. The trifluoromethylthiolation protocol is compatible with a broad substrate scope, providing a variety of 3-((trifluoromethyl)thio)indoles in moderate to good yields within one step, open-air, and short reaction time.

Method for synthesizing trifluoromethyl sulfidethioetherified indole derivatives

The invention discloses a method for synthesizing trifluoromethyl sulfidethioetherified indole derivatives. The method comprises the steps of: performing reaction of sodium trifluoromethylsulfinate with indole derivatives in a solvent in which phosphorus trichloride is uniformly distributed with phosphorus trichloride, wherein the reaction temperature is 60 DEG C and the reaction time is 0.33-10 hours. The mole ratio of sodium trifluoromethylsulfinate to the indole derivatives to phosphorus trichloride is (7.5-5):5:(7.5-5). The raw materials for the synthesis method provided by the invention is cheap and easy to be obtained. The trifluoromethyl sulfidethioetherification reagent used is sodium trifluoromethylsulfinate which is stable in chemical properties, cheap and easy to be obtained.