151899-62-6

Basic information

• Product Name: 3-iodo-1-trityl-1H-1,2,4-triazole
• Synonyms: 3-iodo-1-trityl-1H-1,2,4-triazole;1H-1,2,4-Triazole, 3-iodo-1-(triphenylMethyl)-;3-Iodo-1-(triphenylmethyl)-1H-1,2,4-triazole;3-iodo-1-trityl-1,2,4-triazole
• CAS NO: 151899-62-6
• Molecular Formula: C₂₁H₁₆IN₃
• Molecular Weight: 437.27631
• Mol File: 151899-62-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 560.9±60.0 °C(Predicted)
• Appearance: /
• Density: 1.45±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 0.21±0.50(Predicted)
• CAS DataBase Reference: 3-iodo-1-trityl-1H-1,2,4-triazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-iodo-1-trityl-1H-1,2,4-triazole(151899-62-6)
• EPA Substance Registry System: 3-iodo-1-trityl-1H-1,2,4-triazole(151899-62-6)

Safety Data

• Hazardous Substances Data: 151899-62-6(Hazardous Substances Data)

Usage

General Description

3-iodo-1-trityl-1H-1,2,4-triazole is a chemical compound with the molecular formula C22H17IN4. It is a member of the triazole family of compounds and contains a trityl group and an iodine atom attached to a triazole ring. 3-iodo-1-trityl-1H-1,2,4-triazole is commonly used as a reagent in organic synthesis and as a building block for the preparation of various pharmaceutical and agrochemical products. It has also been researched for its potential antitumor and antimicrobial properties. The compound is generally stable under normal storage and handling conditions, but should be used with caution due to its potentially hazardous nature.

Upstream product

• 6399-81-1 triphenylphosphine hydrobromide 
• 151899-61-5 1-trityl-5-iodo-1,2,4-triazole 
• 31250-99-4 1-triphenylmethyl-1,2,4-triazole 

Downstream Products

• 151899-79-5 1-hydroxy-3(1-trityl-1,2,4-triazol-3-yl)prop-2-yne 
• 151899-71-7 diethyl 3(1-trityl-1,2,4-triazol-3-yl)prop-2-yne phosphonate 
• 1025468-04-5 3-(1-trimethylsilylethyn-2-yl)-1-trityl-1H-1,2,4-triazole 
• 1025468-57-8 (1S)-3-((2S,3R)-2-(4-{4-(acetyloxy)-3-[(acetyloxy)methyl]-3-hydroxybut-1-yn-1-yl}phenyl)-4-oxo-1-{4-[(trityl-1H-1,2,4-triazol-3-yl)ethynyl]phenyl}azetidin-3-yl)-1-(4-fluorophenyl)propyl acetate 
• 1141080-84-3 5-(3-chloro-4-fluorophenyl)-3-methyl-3-(pyrimidin-5-ylmethyl)-1-(1-trityl-1,2,4-triazol-3yl)-1,3-dihydro-2H-indol-2-one 
• 151899-70-6 diethyl Z-3(1-trityl-1,2,4-triazol-3-yl)prop-2-ene phosphonate 
• 151899-81-9 1-iodo-3(1-trityl-1,2,4-triazol-3-yl)prop-2-yne 
• 151899-80-8 1-bromo-3(1-trityl-1,2,4-triazol-3-yl)prop-2-yne 

Relevant articles and documents

HETEROCYCLYL-SUBSTITUTED ANTI-HYPERCHOLESTEROLEMIC COMPOUNDS

This invention provides cholesterol absorption inhibitors of Formula I: and the pharmaceutically acceptable salts thereof, wherein R12 is a hydroxylated alkyl group and R9 contains a heterocyclic ring. The compounds are useful for lowering plasma cholesterol levels, particularly LDL cholesterol, and for treating atherosclerosis and preventing atherosclerotic disease events.

The design and synthesis of inhibitors of imidazoleglycerol phosphate dehydratase as potential herbicides

The discovery and exploration of a new class of broad-spectrum postemergent herbicides with a novel mode of action, namely the disruption of histidine biosynthesis via inhibition of imidazoleglycerol phosphate dehydratase (IGPD; E.C. 4.2.1.19), are described. Clear structural similarities between the first member, produced during an attempt to produce analogues of glyphosate, and intermediates in histidine biosynthesis were noted. Several series of targets were designed, to mimic both the enzyme substrate and a putative reaction intermediate, and synthesised. Some examples were found to be both extremely potent inhibitors of the enzyme, having K(i) values as low as 0·3 nM, and phloem-mobile herbicides with levels of weed control similar to those shown by glyphosate. Further logical progress awaits a high-resolution X-ray structure determination of an enzyme-inhibitor complex.