152121-20-5

Basic information

• Product Name: 2-(4-Cyanophenyl)-4-(4-fluorophenyl)-1-N-hydroxy-5-(4-pyridyl)imidazole
• Synonyms: 2-(4-Cyanophenyl)-4-(4-fluorophenyl)-1-N-hydroxy-5-(4-pyridyl)imidazole
• CAS NO: 152121-20-5
• Molecular Weight: 356.359
• Mol File: 152121-20-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-(4-Cyanophenyl)-4-(4-fluorophenyl)-1-N-hydroxy-5-(4-pyridyl)imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Cyanophenyl)-4-(4-fluorophenyl)-1-N-hydroxy-5-(4-pyridyl)imidazole(152121-20-5)
• EPA Substance Registry System: 2-(4-Cyanophenyl)-4-(4-fluorophenyl)-1-N-hydroxy-5-(4-pyridyl)imidazole(152121-20-5)

Safety Data

• Hazardous Substances Data: 152121-20-5(Hazardous Substances Data)

Upstream product

• 105-07-7 4-cyanobenzaldehyde 
• 108-89-4 picoline 
• 60-29-7 diethyl ether 
• 116332-54-8 4-fluoro-N-methoxy-N-methylbenzamide 
• 6576-05-2 1-(4-fluorophenyl)-2-(4-pyridyl)ethanone 
• 403-43-0 4-fluorobenzoyl chloride 

Downstream Products

• 152121-34-1 2-(4-Aminomethylphenyl)-4-(4-fluorophenyl)-5-(pyridin-4-yl)-1H-imidazole 
• 152121-19-2 2-(4-Cyanophenyl)-4-(4-fluorophenyl)-5-(pyridin-4-yl)-1H-imidazole 

Relevant articles and documents

Treatment for CNS injuries

The present invention is directed to the use of 2,4,5-trisubstituted imidazole compounds and compositions in the treatment of CNS injuries to the brain.

Pyrimidinyl imidazoles

Novel 2,4,5-triaryl imidazole compounds and compositions for use in therapy.

Regulation of stress-induced cytokine production by pyridinylimidazoles inhibition of CSBP kinase

Members of three classes of pyridinylimidazoles bind with varying affinities to CSBP (p38) kinase which is a member of a stress-induced signal transduction pathway. Based upon SAR and protein homology modeling, the pharmacophore and three potential modes of binding to the enzyme are presented. For a subset of pyridinylimidazoles, binding is shown to correlate with inhibition of CSBP kinase activity, whereas no significant inhibition of PKA, PKα and ERK kinase activity is observed.