15251-78-2

Basic information

• Product Name: Methoxymethyl Phenyl Sulfone
• Synonyms: Methoxymethyl Phenyl Sulfone
• CAS NO: 15251-78-2
• Molecular Formula: C₈H₁₀O₃S
• Molecular Weight: 186.2282
• EINECS: -0
• Mol File: 15251-78-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 71.0 to 75.0 °C
• Appearance: /
• CAS DataBase Reference: Methoxymethyl Phenyl Sulfone(CAS DataBase Reference)
• NIST Chemistry Reference: Methoxymethyl Phenyl Sulfone(15251-78-2)
• EPA Substance Registry System: Methoxymethyl Phenyl Sulfone(15251-78-2)

Safety Data

• Hazardous Substances Data: 15251-78-2(Hazardous Substances Data)

Usage

General Description

Methoxymethyl phenyl sulfone is a chemical compound that contains a sulfonyl group and a methoxymethyl substituent attached to a phenyl ring. It is commonly used as a building block in organic synthesis, particularly in the production of various pharmaceuticals and agrochemicals. Methoxymethyl Phenyl Sulfone is also utilized as an intermediate in the manufacture of dyes and pigments. Methoxymethyl phenyl sulfone has demonstrated potential as an effective UV-protective agent and is being researched for potential applications in sunscreen formulations. Additionally, it is a versatile material in material science and polymer chemistry, contributing to the development of polymers with desirable properties for various industrial applications.

Upstream product

• 13865-50-4 methoxymethyl phenyl sulfide 
• 108-98-5 thiophenol 
• 873-55-2 sodium benzenesulfonate 
• 107-30-2 chloromethyl methyl ether 
• 13057-17-5 bromethyl methyl ether 
• 109-87-5 Dimethoxymethane 
• 618-41-7 Benzenesulfinic acid 

Downstream Products

• 127237-62-1 (Cyclohexylidene-methoxy-methanesulfonyl)-benzene 
• 89036-94-2 1-(Benzenesulfonyl-methoxy-methyl)-cyclohexanol 
• 4747-15-3 1-(2-methoxyvinyl)benzene 
• 75456-62-1 (4-methoxybut-3-en-1-yl)benzene 
• 70499-55-7 Benzenesulfonyl-methoxy-acetic acid methyl ester 
• 60417-14-3 α-Methoxy-α-phenylsulfonylacetaldehyd 
• 49538-11-6 2-Benzenesulfonyl-1-(4-chloro-phenyl)-2-methoxy-ethanone 
• 19820-37-2 -methyl-ether 

Relevant articles and documents

Enantioselective Aromatic Sulfide Oxidation and Tandem Kinetic Resolution Using Aqueous H2O2 and Chiral Iron–Bis(oxazolinyl)bipyridine Catalysts

An efficient method for the oxidation of aromatic sulfides has been developed by using aqueous H2O2, catalyzed by the in situ generated chiral Fe/6,6′-bis(4-isopropyloxazolin-2-yl)-2,2′-bipyridine (bipybox-iPr) complex. The corresponding sulfoxides were obtained with high enantioselectivities (up to 98.5:1.5 er) and in good yields (up to 61 %) when the mono-oxidation of the sulfides was performed in combination with the kinetic resolution of the sulfoxide into the sulfone.

Chromium(VI) oxide catalyzed oxidation of sulfides to sulfones with periodic acid

A highly efficient and selective oxidation of sulfides to sulfones with periodic acid catalyzed by CrO3 is described. A variety of electron-rich and electron-deficient sulfides were oxidized to sulfones with 2 mol% CrO3 in acetonitrile at room temperature in excellent yields. Sulfides with other readily oxidized functional groups were selectively oxidized to sulfones in high yields with 10 mol% CrO3 in ethyl acetate/acetonitrile at -35 °C.

Ketone homologation to produce α-methoxyketones: Application to conduritol synthesis

The scope of Trost's sulfone homologation procedure for the conversion of ketones into their α-methoxylated higher homologues has been dramatically expanded. The use of zirconium (or hafnium) tetrachloride in the hydroxy sulfone rearrangement step gives g