1527-13-5Relevant articles and documents
Discovery and Optimization of Thiazolidinyl and Pyrrolidinyl Derivatives as Inhaled PDE4 Inhibitors for Respiratory Diseases
Carzaniga, Laura,Amari, Gabriele,Rizzi, Andrea,Capaldi, Carmelida,De Fanti, Renato,Ghidini, Eleonora,Villetti, Gino,Carnini, Chiara,Moretto, Nadia,Facchinetti, Fabrizio,Caruso, Paola,Marchini, Gessica,Battipaglia, Loredana,Patacchini, Riccardo,Cenacchi, Valentina,Volta, Roberta,Amadei, Francesco,Pappani, Alice,Capacchi, Silvia,Bagnacani, Valentina,Delcanale, Maurizio,Puccini, Paola,Catinella, Silvia,Civelli, Maurizio,Armani, Elisabetta
supporting information, p. 10026 - 10046 (2018/01/10)
Phosphodiesterase 4 (PDE4) is a key cAMP-metabolizing enzyme involved in the pathogenesis of inflammatory disease, and its pharmacological inhibition has been shown to exert therapeutic efficacy in chronic obstructive pulmonary disease (COPD). Herein, we describe a drug discovery program aiming at the identification of novel classes of potent PDE4 inhibitors suitable for pulmonary administration. Starting from a previous series of benzoic acid esters, we explored the chemical space in the solvent-exposed region of the enzyme catalytic binding pocket. Extensive structural modifications led to the discovery of a number of heterocycloalkyl esters as potent in vitro PDE4 inhibitors. (S?,S??)-18e and (S?,S??)-22e, in particular, exhibited optimal in vitro ADME and pharmacokinetics properties and dose-dependently counteracted acute lung eosinophilia in an experimental animal model. The optimal biological profile as well as the excellent solid-state properties suggest that both compounds have the potential to be effective topical agents for treating respiratory inflammatory diseases.
Palladium-catalyzed carbon-sulfur cross-coupling reactions with indium tri(organothiolate) and its application to sequential one-pot processes
Lee, Jae-Young,Phil, Ho Lee
supporting information; experimental part, p. 7413 - 7416 (2009/05/07)
(Chemical Equation Presented) It was found that indium tri(organothiolate) is an effective nucleophilic coupling partner in Pd-catalyzed C-S cross-coupling reactions to produce the functionalized sulfides in excellent yields with high atom efficiency and
Reactions of N-sulfenyl-1,2-benzisothiazolin-3-ones with nucleophiles
Bao, Ming,Shimizu, Masao,Shimada, Shigeru,Inoue, Jun'ichi,Konakahara, Takeo
, p. 11359 - 11366 (2007/10/03)
Reactions of N-[2-(alkoxycarbonyl)benzenesulfenyl]-1,2-benzisothiazolin-3- ones (1) with various nucleophiles were examined. Anions of active methylene compounds attacked the sulfur atoms of the sulfenyl moieties of 1 to afford sulfide compounds, while th
