152802-65-8

Basic information

• Product Name: ETHYL 2-AMINO-2-ETHYLHEXANOATE
• Synonyms: ETHYL 2-AMINO-2-ETHYLHEXANOATE;2-Amino-2-ethylhexanoic acid ethyl ester;DL-Norleucine, 2-ethyl-, ethyl ester
• CAS NO: 152802-65-8
• Molecular Formula: C₁₀H₂₁NO₂
• Molecular Weight: 187.28
• Mol File: 152802-65-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 232.8°C at 760 mmHg
• Flash Point: 99.4°C
• Appearance: /
• Density: 0.932g/cm³
• Vapor Pressure: 0.058mmHg at 25°C
• Refractive Index: 1.446
• Storage Temp.: 2-8°C
• CAS DataBase Reference: ETHYL 2-AMINO-2-ETHYLHEXANOATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-AMINO-2-ETHYLHEXANOATE(152802-65-8)
• EPA Substance Registry System: ETHYL 2-AMINO-2-ETHYLHEXANOATE(152802-65-8)

Safety Data

• Hazardous Substances Data: 152802-65-8(Hazardous Substances Data)

Usage

General Description

ETHYL 2-AMINO-2-ETHYLHEXANOATE is a chemical compound more commonly known as Ethyl Amino Neoheptanoate. It is primarily used in the soap and detergent industry, where it acts as a surfactant. This means it helps to reduce the surface tension of water, making it more effective at removing dirt and debris. This chemical is also used as an ingredient in cosmetics products due to its skin-conditioning and moisturizing properties, where it can also function as a hair conditioning agent. In these applications, Ethyl Amino Neoheptanoate can enhance the texture and feel of the product, leading to a more pleasurable consumer experience. It is a pale yellow viscous liquid with a relatively high boiling point. The safety of this chemical is continuously evaluated by the Cosmetic Ingredient Review, which so far has deemed it safe for use in cosmetic products.

InChI:InChI=1/C10H21NO2/c1-4-7-8-10(11,5-2)9(12)13-6-3/h4-8,11H2,1-3H3

Upstream product

• 64-17-5 ethanol 
• 6300-78-3 2-Amino-2-ethyl-hexanoic acid 
• 55410-21-4 ethyl 2-aminobutyrate hydrochloride 
• 78843-65-9 Ethyl (E)-2-(benzylideneamino) butanoate 
• 58577-05-2 2-amino-2-ethylhexanonitrile 
• 106-35-4 heptan-3-one 
• 152802-64-7 ethyl 2-(benzylideneamino)-2-ethylhexanoate 

Downstream Products

• 114781-15-6 (S)-2-amino-2-ethylhexanoic acid 
• 151851-75-1 (+/-)-2-amino-2-ethylhexan-1-ol 
• 151851-75-1 (R)-2-amino-2-ethylhexan-1-ol 
• 114781-14-5 (R)-2-amino-2-ethylhexanoic acid 
• 164262-42-4 ethyl (S)-2-amino-2-ethylhexanoate 

Relevant articles and documents

BENZOTHIA(DI)AZEPINE COMPOUNDS AND THEIR USE AS BILE ACID MODULATORS

The invention relates to certain 1,5-benzothiazepine and 1,2,5-benzothiadiazepine derivatives as defined herein. These compounds are bile acid modulators having apical sodium-dependent bile acid transporter (ASBT) and/or liver bile acid transport (LBAT) inhibitory activity. The invention also relates to pharmaceutical compositions comprising these compounds and to the use of these compounds in the treatment of cardiovascular diseases, fatty acid metabolism and glucose utilization disorders, gastrointestinal diseases and liver diseases.

BENZOTHIA(DI)AZEPINE COMPOUNDS AND THEIR USE AS BILE ACID MODULATORS

The invention relates to 1,5-benzothiazepine and 1,2,5-benzothiadiazepine derivatives of formula (I). These compounds are bile acid modulators having apical sodium-dependent bile acid transporter (ASBT) and/or liver bile acid transport (LBAT) inhibitory activity. The invention also relates to pharmaceutical compositions comprising these compounds and to the use of these compounds in the treatment of cardiovascular diseases, fatty acid metabolism and glucose utilization disorders, gastrointestinal diseases and liver diseases.

The first fully planar C5-conformation of homooligopeptides prepared from a chiral α-ethylated α,α-disubstituted amino acid: (S)-butylethylglycine (=(2S)-2-amino-2-ethylhexanoic acid)

An optically active α-ethylated α,α-disubstituted amino acid, (S)-butylethylglycine (=(2S)-2-amino-2-ethylhexanoic acid; (S)-Beg; (S)-2), was prepared starting from butyl ethyl ketone (1) by the Strecker method and enzymatic kinetic resolution of the racemic amino acid. Homooligopeptides containing (S)-Beg (up to hexapeptide) were synthesized by conventional solution methods. An ethyl ester was used for the protection at the C-terminus, and a trifluoroacetyl group was used for the N-terminus of the peptides. The structures of tri-and tetrapeptides 5 and 6 in the solid state were solved by X-ray crystallographic analysis, and were shown to have a bent planar C5-conformation (tripeptide) and a fully planar C5-conformation (tetrapeptide) (see Figs. 1 and 2, resp.). The IR and 1H-NMR spectra of hexapeptide 8 revealed that the dominant conformation in CDCl3 solution was also a fully planar C5-conformation. These results show for the first time that the preferred conformation of homopeptides containing a chiral α-ethylated α,α-disubstituted amino acid is a planar C5-conformation.