153168-05-9 Usage
Description
PLECONARIL is a drug with antiviral activity, characterized by its off-white solid chemical properties. It has been utilized in the development and assessment of antiviral compounds against various picornaviruses.
Uses
Used in Pharmaceutical Industry:
PLECONARIL is used as a control or reference compound for evaluating the antiviral activities of benzothiophene and other heteroaromatic derivatives against different human rhinoviruses (hRV-B14, hRV-A21, and hRV-A71). This application aids in the development of more effective antiviral agents.
Used in Antiviral Research:
As a picornavirus replication inhibitor, PLECONARIL is used in antiviral research to study and combat viral infections. Its role in inhibiting the replication of picornaviruses makes it a valuable tool in the development of new antiviral treatments.
Pharmaceutical Applications
An oxadiazole active against most enteroviruses and rhinoviruses.
It binds to the hydrophobic pocket of the virus capsid
protein VP1, inducing conformational changes that lead to
altered receptor binding and viral uncoating. Concerns over
safety and efficacy have constrained development of the drug.
Biochem/physiol Actions
Pleconaril is an effective drug against enteroviral infections. It can be used to treat chronic meningoencephalitis caused by echo virus 6.This can block viral replication by blocking the viral uncoating process and viral attachment to host cell receptors.
Check Digit Verification of cas no
The CAS Registry Mumber 153168-05-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,3,1,6 and 8 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 153168-05:
(8*1)+(7*5)+(6*3)+(5*1)+(4*6)+(3*8)+(2*0)+(1*5)=119
119 % 10 = 9
So 153168-05-9 is a valid CAS Registry Number.
InChI:InChI=1/C18H18F3N3O3/c1-10-7-13(16-22-17(27-24-16)18(19,20)21)8-11(2)15(10)25-6-4-5-14-9-12(3)23-26-14/h7-9H,4-6H2,1-3H3
153168-05-9Relevant articles and documents
1,2,4-OXADIAZOLYL-PHENOXYALKYLISOXAZOLES AND THEIR USE AS ANTIVIRAL AGENTS
-
, (2008/06/13)
Compounds of the formula wherein: R1 is alkyl, alkoxy, hydroxy, cycloalkyl, hydroxyalkyl, alkoxyalkyl, hydroxyalkoxy, alkylthioalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkoxycarbonyl, carboxy, or cyanomethyl; Y is alkylene of 3 to 9 carbon atoms, R2 and R3 independently are hydrogen, alkyl, alkoxy, halo, cyano, trifluoromethyl and nitro; R4 is alkoxy, hydroxy, halomethyl, dihalomethyl, trihalomethyl, dihaloethyl, cycloalkyl, heterocyclyl, alkoxycarbonyl, hydroxyalkyl, alkoxyalkyl, alkanecarbonyloxyalkyl, cyano, halo, thioalkyl, alkylthioalkyl, alkylthio, thio, 2,2,2-trifluoro-ethyl, (4-methylphenyl)sulfonyloxymethyl, N=Q or CON=Q, where N=Q is amino, alkylamino or dialkylamino; R5 is hydrogen or halo or alkyl
1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
-
, (2008/06/13)
Compounds of the formula STR1 wherein: R1 is alkyl, alkoxy, hydroxy, cycloalkyl, hydroxyalkyl, alkoxyalkyl or hydroxyalkoxy; Y is alkylene of 3 to 9 carbon atoms, R2 and R3 independently are hydrogen, alkyl, alkoxy, halo,
