153322-06-6

Basic information

• Product Name: Lanicemine dihydrochloride
• Synonyms: (αS)-α-Phenyl-2-pyridineethanamine dihydrochloride;AR-R 15896 dihydrochloride;AZD6765 dihydrochloride;FPL 15896 dihydrochloride;Lanicemine dihydrochloride;ARL-15896;AZD6765
• CAS NO: 153322-06-6
• Molecular Formula: C13H16Cl2N2
• Molecular Weight: 271.18554
• Mol File: 153322-06-6.mol
• Article Data: 0

Chemical Properties

• Appearance: white to beige/
• Storage Temp.: 2-8°C
• Solubility: H2O: soluble20mg/mL, clear
• CAS DataBase Reference: Lanicemine dihydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Lanicemine dihydrochloride(153322-06-6)
• EPA Substance Registry System: Lanicemine dihydrochloride(153322-06-6)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 153322-06-6(Hazardous Substances Data)

Usage

Description

Lanicemine dihydrochloride, a chemical compound, is utilized in various applications across different industries due to its unique properties and characteristics.

Uses

Used in Pharmaceutical Industry:
Lanicemine dihydrochloride is used as an antidepressant for improving behavior and metabolic measures in patients experiencing chronic unpredictable mild stress (CUMS). Its effectiveness in this application is attributed to its ability to modulate the neurochemical processes involved in mood regulation and stress response, thereby providing relief from depressive symptoms.

Biochem/physiol Actions

AZD6765 is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist and fast-acting antidepressant. In a recent study AZD6765 relieved depression within 80 minutes, unlike most antidepressants acting on serotonin or dopamine systems which can take several weeks to work. The effects lasted from about an hour up to 2 weeks. AZD6765 has an IC50 value of 1.3 μM. Unlike more potent drugs such as ketamine, which also has rapid antidepressant activity, AZD6765 has no dissociative side-effects such as hallucinations. Earlier studies inidcated the compound has neuroprotective and anticonvulsant effects.