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15366-32-2

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15366-32-2 Usage

General Description

Creatine ethyl ester hydrochloride is a synthetic form of the organic compound creatine, which is found naturally in the body and is also commonly used as a dietary supplement by athletes and bodybuilders. This particular form of creatine is bound to an ethyl ester group, which is thought to improve its absorption and bioavailability in the body compared to other forms of creatine. The addition of the hydrochloride component to creatine ethyl ester is believed to further enhance its solubility and stability. As a result, creatine ethyl ester hydrochloride is often promoted for its potential to increase muscle mass, enhance athletic performance, and improve exercise endurance. However, there is limited scientific evidence to support these claims, and the safety and long-term effects of this compound are still under investigation.

Check Digit Verification of cas no

The CAS Registry Mumber 15366-32-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,3,6 and 6 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 15366-32:
(7*1)+(6*5)+(5*3)+(4*6)+(3*6)+(2*3)+(1*2)=102
102 % 10 = 2
So 15366-32-2 is a valid CAS Registry Number.
InChI:InChI=1/C6H13N3O2.ClH/c1-3-11-5(10)4-9(2)6(7)8;/h3-4H2,1-2H3,(H3,7,8);1H

15366-32-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name Creatine ethyl ester hydrochloride

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:15366-32-2 SDS

15366-32-2Downstream Products

15366-32-2Relevant articles and documents

Novel synthetic process for creatine ethyl ester hydrochloride

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Paragraph 0012; 0029; 0031-0035, (2019/01/05)

The invention provides a novel synthetic process for creatine ethyl ester hydrochloride. The novel synthetic process comprises the following synthetic steps: with 4-dimethylaminopyridine (DMAP) as a catalyst and thionyl chloride or carbonyl chloride as a reaction dehydrating agent, allowing creatine to react in absolute ethyl alcohol at a low temperature so as to obtain the creatine ethyl ester hydrochloride. According to the invention, the catalyst effectively improves the rate of an esterification reaction between the creatine and ethyl alcohol, reduces the occurrence of a creatinine side reaction, and improves the purity of the creatine ethyl ester hydrochloride. The overall process provided by the invention basically belongs to a normal-temperature and normla-pressure process, and haslow energy consumption, high creatine conversion rate and high product purity.

Synthesis and biological evaluation of new creatine fatty esters revealed Dodecyl creatine ester as a promising drug candidate for the treatment of the creatine transporter deficiency

Trotier-Faurion, Alexandra,Dézard, Sophie,Taran, Frédéric,Valayannopoulos, Vassili,De Lonlay, Pascale,Mabondzo, Alo?se

, p. 5173 - 5181 (2013/07/26)

The creatine transporter deficiency is a neurological disease caused by impairment of the creatine transporter SLC6A8, resulting in mental retardation associated with a complete absence of creatine within the brain and cellular energy perturbation of neuronal cells. One of the therapeutic hypotheses was to administer lipophilic creatine derivatives which are (1) thought to have better permeability through the cell membrane and (2) would not rely on the activity of SLC6A8 to penetrate the brain. Here, we synthesized creatine fatty esters through original organic chemistry process. A screening on an in vitro rat primary cell-based blood-brain barrier model and on a rat primary neuronal cells model demonstrated interesting properties of these prodrugs to incorporate into endothelial, astroglial, and neuronal cells according to a structure-activity relationship. Dodecyl creatine ester showed then a 20-fold increase in creatine content in pathological human fibroblasts compared with the endogenous creatine content, stating that it could be a promising drug candidate.

Labeled creatine ethyl ester hydrochloride

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Page/Page column 1, (2008/06/13)

The present invention relates to various radiolabeled creatine ethyl ester hydrochloride compounds. Any carbon, hydrogen or nitrogen atom of the compounds may be radiolabeled using 14C, 13C, 2H, 3H or 15N atoms.

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