153705-03-4

Basic information

• Product Name: 5-<(3-hydroxy-1-phenylpyrrol-2-yl)methylene>-2,2-dimethyl-1,3-dioxane-4,6-dione
• CAS NO: 153705-03-4
• Molecular Weight: 313.31
• Mol File: 153705-03-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-<(3-hydroxy-1-phenylpyrrol-2-yl)methylene>-2,2-dimethyl-1,3-dioxane-4,6-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-<(3-hydroxy-1-phenylpyrrol-2-yl)methylene>-2,2-dimethyl-1,3-dioxane-4,6-dione(153705-03-4)
• EPA Substance Registry System: 5-<(3-hydroxy-1-phenylpyrrol-2-yl)methylene>-2,2-dimethyl-1,3-dioxane-4,6-dione(153705-03-4)

Safety Data

• Hazardous Substances Data: 153705-03-4(Hazardous Substances Data)

Upstream product

• 15568-85-1 5-methoxymethylene-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 134410-07-4 3-hydroxy-1-phenylpyrrole 

Relevant articles and documents

3-Hydroxypyrroles and 1H-Pyrrol-3(2H)-ones. Part 13. Reactions of Methoxymethylene Meldrum's Acids with 3-Hydroxypyrroles, with 3-Methoxypyrroles and with other Active Substrates, and Pyrolytic Heterocyclizations of the Products

Methoxymethylene Meldrum's acid 2 in acetonitrile solution acts a useful C-electrophile for active substrates such as pyrrole, indole or tertiary enaminones to give substitution products (e.g. 5, 6 or 12, respectively).Primary enaminones react exlusively at the nitrogen atom under these conditions.The effect of the ring substituents on the regiochemistry of electrophilic substitution of 3-hydroxypyrroles and 3-methoxypyrroles was studied using methoxymethylene Meldrum's acid as the electrophile.Flash vacuum pyrolysis of the Meldrum's acid derivatives obtained in many of these reactions gave access to a range of heterocyclic systems, including the pyridone 48, quinolinedione 43, benzazepinedione 41 and fused pyrones 50, 52 and 54.