1538-08-5

Basic information

• Product Name: TRIFLUOROACETIC ACID HYDRAZIDE
• Synonyms: TRIFLUOROACETIC ACID HYDRAZIDE;2,2,2-Trifluoroacetohydrazide;Trifluoroacetyl Hydrazide;Acetic acid, 2,2,2-trifluoro-, hydrazide;2,2,2-trifluoroAcetic acid hydrazide
• CAS NO: 1538-08-5
• Molecular Formula: C₂H₃F₃N₂O
• Molecular Weight: 128.05
• Mol File: 1538-08-5.mol
• Article Data: 30

Chemical Properties

• Melting Point: 111 °C
• Boiling Point: 192.3 °C at 760 mmHg
• Flash Point: 70.1 °C
• Appearance: /
• Density: 1.462 g/cm³
• Vapor Pressure: 0.493mmHg at 25°C
• Refractive Index: 1.351
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 9.47±0.20(Predicted)
• CAS DataBase Reference: TRIFLUOROACETIC ACID HYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: TRIFLUOROACETIC ACID HYDRAZIDE(1538-08-5)
• EPA Substance Registry System: TRIFLUOROACETIC ACID HYDRAZIDE(1538-08-5)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 1538-08-5(Hazardous Substances Data)

Usage

General Description

TRIFLUOROACETIC ACID HYDRAZIDE, also known as trifluoroacetyl hydrazide, is a chemical compound with the formula CF3CONHNH2. It is a colorless, odorless solid that is highly soluble in water and polar organic solvents. TRIFLUOROACETIC ACID HYDRAZIDE is commonly used as a reagent in organic synthesis for the preparation of heterocyclic compounds, as well as a derivatization reagent in mass spectrometry for the analysis of biomolecules. It is also used in the production of pharmaceuticals and agrochemicals. However, TRIFLUOROACETIC ACID HYDRAZIDE is considered to be toxic and should be handled with care, as it can cause skin and eye irritation upon contact.

InChI:InChI=1/C2H3F3N2O/c3-2(4,5)1(8)7-6/h6H2,(H,7,8)

Upstream product

• 431-47-0 trifluoroacetic acid-methyl ester 
• 76-05-1 trifluoroacetic acid 
• 383-63-1 ethyl trifluoroacetate, 
• 302-01-2 hydrazine 
• 407-25-0 trifluoroacetic anhydride 
• 220294-74-6 N-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2,2,2-trifluoro-acetamide 

Downstream Products

• 768-29-6 5-(trifluoromethyl)-1,3,4-oxadiazol-2-amine 
• 257885-38-4 2-[N'-(2,2,2-Trifluoro-acetyl)-hydrazinocarbonyl]-benzoic acid 
• 216504-41-5 4-[5-(3-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]pyridine 
• 723286-98-4 2-trifluoromethyl-1,3,4-oxadiazol-5-ylmethyl chloride 
• 1452467-20-7 (2R,5R)-6-(benzyloxy)-7-oxo-N’-(trifluoroacetyl)-1,6-diazabicyclo[3.2.1]octane-2-carbohydrazide 
• 667-35-6 1,2-bis(trifluoroacetyl)hydrazine 

Relevant articles and documents

Design, synthesis, biological evaluation and computational study of novel triazolo [4,3-a]pyrazin analogues

The triazolo [4,3-a]pyrazin analogues are of interest due to their potential activity against various infectious and non-infectious disease. In search of suitable potent drug candidate, we report here the design, synthesis, characterization, biological activities and computation study of novel triazolo [4,3-a]pyrazin analogues. The synthesized molecules were characterized by various spectroscopic studies such as IR, Mass, 1H NMR, 13C NMR and elemental analysis. The newly synthesized compounds were evaluated for their in vitro biological activities such as anti-malarial, anti-tuberculosis, anti-bacterial and anti-fungal activities against plasmodium falciparum, H37Rv, various bacterial and fungal strains, respectively. The molecular docking study was carried out with enzyme aspartic proteinase zymogen proplasmepsin II from plasmodium falciparum to analyze their binding orientation in the active site of the aspartic proteinase enzyme. The best docking complex was subjected to molecular dynamics simulation to illustrate the stability of these complexes and the most prominent interactions during the simulated trajectory. We have also calculated ADMET properties of all the synthesized compounds to predict the pharmacokinetic properties for the selection of the active and bioavailability of compounds.

Blue phosphorescent bipyridine-based iridium(III) complex for vacuum-deposited organic light-emitting diodes

We have synthesized and characterized a blue phosphorescent iridium(III) complex (dfpypy)2Ir(tftamp), which contains 2,6-difluoro-2,3-bipyridine (dfpypy) as the main ligand and 4-methyl-2-(3-trifluoromethyl-1H-1,2,4-triazol-5-yl)pyridine (tftamp) as the ancillary ligand. The photophysical, electrochemical, and electroluminescent (EL) properties of (dfpypy)2Ir(tftamp) were investigated. Vacuum-deposited blue and white organic light-emitting diodes (OLEDs) were fabricated using (dfpypy)2Ir(tftamp) in 1,3-bis(carbazol-9-yl)benzene (mCP) as the emitting layer. The EL spectrum of (dfpypy)2Ir(tftamp) exhibited emission maximum at 472 nm with a full-width at half-maximum (FWHM) of 81 nm and Commission Internationale de L’Eclairage (CIE) coordinates of (0.17, 0.27) at 100 cd · m?2. In addition, white-light-emitting devices were fabricated, which exhibited CIE coordinates of (0.42, 0.40) and a correlated color temperature (CCT) of 3,237 K at 1000 cd · m?2, close to the standard warm-white light CIE coordinates of (0.44, 0.40) and CCT of 3,000 K.

Efficient synthesis of tri- and difluoroacetyl hydrazides as useful building blocks for non-symmetrically substituted, fluoroalkylated 1,3,4-oxadiazoles

[Figure not available: see fulltext.] A convenient and efficient approach to 2-arylamino-5-fluoroalkyl-1,3,4-oxadiazoles has been established via heterocyclization of tri- and difluoroacetylated thiosemicarbazides using dicyclohexylcarbodiimide. A heteroc