153851-71-9 Usage
Description
Biapenem Side Chain is a pharmaceutical raw material utilized in the production of Biapenem antibiotics. It is a crucial component in the synthesis of Biapenem (LJC 10627), a carbapenem antibiotic developed by the Japanese Lederle Company and American Cyanamid Company in 1989. This antibiotic is currently in the final stages of clinical trials in Japan, awaiting approval. The unique feature of Biapenem lies in its bicyclic triazole 1β-methyl carbapenem structure at the 2-position, which significantly enhances its permeability and effectiveness against various bacteria, including pseudomonas aeruginosa, anaerobic bacteria, drug-resistant pseudomonas aeruginosa, acinetobacter, and other bacteria.
Uses
Used in Pharmaceutical Industry:
Biapenem Side Chain is used as a key component in the production of Biapenem antibiotics for the following reasons:
1. It enhances the antibiotic's ability to inhibit the activity of pseudomonas aeruginosa and anaerobic bacteria, making it 2 to 4 times more effective than imipenem.
2. It increases the antibiotic's effectiveness against drug-resistant pseudomonas aeruginosa, making it 4 to 8 times more potent than Meropenem.
3. It provides a more effective impact on acinetobacter and anaerobic bacteria compared to ceftazidime.
Additionally, the presence of the side chain quaternary ammonium cation center is essential for affecting the permeability of the outer membrane, which contributes to the overall effectiveness of the antibiotic.
Reference quality standards
Appearance: white to yellowish crystalline powder
Determination of content: 98%
Specific rotation:-26.0 ° to-36.0 °
pH: 4.5 to 6.0
Single Impurity: <1.0%
Total Impurities: <3.0%
Tetrahydrofuran and acetone: tetrahydrofuran less than 0.072%, acetone less than 0.5%
Loss on drying: no more than 1.0%
Residue on ignition: no more than 0.2%
Heavy metals: no more than 20ppm
The current status of Chinese imipenem drugs
Penem drugs are the antibiotics that have the most wide antibacterial spectrum and stronger antibacterial activity, and therefore play an important role for the last line of defense of serious anti-clinical infection. In recent years, the serious problem of drug-resistant bacteria make the use of these drugs in the global and domestic have a rapid growth, and the world has listed 6 drug types of imipenem-cilastatin, panipenem-betamipron, meropenem, biapenem (Biopenone Side Chain), ertapenem and doripenem. However, the penem drugs is clinically used as a second-line drug, the government's guiding principle for rational application of antibiotics and the expensive price all greatly limit the use expansion of these drugs. These factors determine that this class of drugs in the short term is still a "nobility" variety with high added value and small scale. In 2008, the terminal sales scale of penem drugs in Chinese market was 19.9 billion yuan (equivalent to US $ 278 million), accounting for 9% of the global total sales (nearly $ 3 billion). The sales mumble was about 12.43 million and the consumption of raw materials was 5~6 ton/year, in which domestic raw materials were 1.9 tons (1.8 tons of meropenem, 0.14 tons of imipenem) and accounted for 36%.
In the raw material export market of 2008, the raw materials export volume of the three major penem products of China (meropenem, imipenem and intermediate 4-AA) were respectively 6 tons, 1.3 tons and 40 tons, accounting for more than 60% of the global generic drug market demand for raw materials.
Since 2009, with the continuous growth of international market demand, China's technical costs of raw materials and intermediates gradually have advantages, especially meropenem shares a larger share in the international market and has a certain discourse power of price. In 2009, the annual export volume of meropenem and 4-AA is expected to reach 8 tons and 50 tons, with a growth rate of about 30%. Penem drugs will continue to grow rapidly and steadily according to their "rhythm".
Check Digit Verification of cas no
The CAS Registry Mumber 153851-71-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,3,8,5 and 1 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 153851-71:
(8*1)+(7*5)+(6*3)+(5*8)+(4*5)+(3*1)+(2*7)+(1*1)=139
139 % 10 = 9
So 153851-71-9 is a valid CAS Registry Number.
InChI:InChI=1/C5H7N3S.ClH/c9-5-1-7-3-6-4-8(7)2-5;/h3-5H,1-2H2;1H
