153880-70-7

Basic information

• Product Name: Propanamide, 2-bromo-N-(4-ethoxyphenyl)-N-methyl-
• CAS NO: 153880-70-7
• Molecular Formula: C12H16BrNO2
• Molecular Weight: 286.169
• Mol File: 153880-70-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Propanamide, 2-bromo-N-(4-ethoxyphenyl)-N-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanamide, 2-bromo-N-(4-ethoxyphenyl)-N-methyl-(153880-70-7)
• EPA Substance Registry System: Propanamide, 2-bromo-N-(4-ethoxyphenyl)-N-methyl-(153880-70-7)

Safety Data

• Hazardous Substances Data: 153880-70-7(Hazardous Substances Data)

Upstream product

• 3154-18-5 N-methyl-p-phenetidine 
• 563-76-8 α-bromopropionyl bromide 

Downstream Products

• 159652-56-9 (+)-(3aR)-N¹-benzylnoreseroline phenylcarbamate 
• 164455-08-7 (+)-(3aR)-N¹-benzylnoreseromethole 
• 116707-99-4 1,3-dimethyl-5-methoxyindolin-2-one 
• 1010-68-0 1,3-dimethyl-5-hydroxyoxindole 

Relevant articles and documents

Racemic N1-norphenserine and its enantiomers: Unpredicted inhibition of human acetyl- and butyrylcholinesterase and β-amyloid precursor protein in vitro

The optically pure enantiomers of N1-norphenserine (15, 16) were synthesized and its racemate 17 was prepared by mixing equal parts of each enantiomer. (-)-N1-Norphenserine (15) was prepared by partial synthesis initiated from the natural product, (-)-physostigmine (1). (+)-N 1-Norphenserine (16) was prepared by total synthesis using the Julian oxindole route, with modifications. The in vitro inhibitory activities of 15-17 were quantified against human erythrocyte AChE and plasma BChE as well as against human neuroblastoma cell β-amyloid precursor protein secretion in cell culture. All were active. Racemic compound (17) with a high AChE and β-amyloid precursor protein inhibitory action may warrant further assessment in Alzheimer's disease models.