154-68-7

Basic information

• Product Name: ANTAZOLINE PHOSPHATE
• Synonyms: N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-N-(phenylmethyl)aniline;N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-N-(phenylmethyl)aniline hydrochloride;N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline hydrochloride;HISTOSAB PHOSPHATE;ANTISTIN PHOSPHATE;ANTAZOLINE H3PO4;ANTAZOLINE PHOSPHATE;ANTAZOLINE PHOSPHATE SALT
• CAS NO: 154-68-7
• Molecular Formula: C17H22N3O4P
• Molecular Weight: 363.35
• EINECS: 205-831-4
• Mol File: 154-68-7.mol
• Article Data: 2

Chemical Properties

• Melting Point: 194-198°
• Boiling Point: 475.5 °C at 760 mmHg
• Flash Point: 241.4 °C
• Appearance: COA
• Vapor Pressure: 3.31E-09mmHg at 25°C
• Storage Temp.: Refrigerator
• Solubility: DMSO, Methanol
• CAS DataBase Reference: ANTAZOLINE PHOSPHATE(CAS DataBase Reference)
• NIST Chemistry Reference: ANTAZOLINE PHOSPHATE(154-68-7)
• EPA Substance Registry System: ANTAZOLINE PHOSPHATE(154-68-7)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 154-68-7(Hazardous Substances Data)

Usage

Uses

Antazoline Phosphate acts as a histamine H1 receptor blocker, functioning as an antihistamine pharmaceutical.

General Description

Antazoline phosphate, 2-[(Nbenzylanilino)methyl]-2-imidazoline dihydrogen phosphate,is a bitter, white to off-white crystalline powder thatis soluble in water. It has a pKa of 10.0, and a 2% solutionhas a pH of about 4.5. Antazoline, like the ethylenediamines,contains an N-benzylanilino group linked to a basicnitrogen through a two-carbon chain.Antazoline is less active than most of the other antihistaminicdrugs, but it is characterized by the lack of local irritation.The more soluble phosphate salt is applied topicallyto the eye in a 0.5% solution. The less soluble hydrochlorideis given orally. In addition to its use as an antihistamine, antazolinehas more than twice the local anesthetic potency ofprocaine and also exhibits anticholinergic actions.

InChI:InChI=1/C17H19N3.H3O4P/c1-3-7-15(8-4-1)13-20(14-17-18-11-12-19-17)16-9-5-2-6-10-16;1-5(2,3)4/h1-10H,11-14H2,(H,18,19);(H3,1,2,3,4)

Relevant articles and documents

Opthalmic solution

An ophthalmic solution is provided for treatment of "dry eye", providing lubricating and cushioning effects for traumatized eyes, including trauma caused by the wearing of hard or gel-type contact lenses, and as a carrier for ophthalmic medicaments. The solution is an aqueous solution of polyethylene oxide, optionally polyethylene glycol, and other optional ingredients.