154371-25-2

Basic information

• Product Name: 1-(3-CHLORO-4-FLUOROPHENYL)-2-THIOUREA
• Synonyms: 1-(3-CHLORO-4-FLUOROPHENYL)-2-THIOUREA;(3-CHLORO-4-FLUORO-PHENYL)-THIOUREA;2-Chloro-1-fluoro-4-thioureidobenzene, 4-(Carbamothioylamino)-2-chloro-1-fluorobenzene
• CAS NO: 154371-25-2
• Molecular Formula: C₇H₆ClFN₂S
• Molecular Weight: 204.65
• Product Categories: Sulphur Derivatives
• Mol File: 154371-25-2.mol
• Article Data: 6

Chemical Properties

• Melting Point: 179.0 to 183.0 °C
• Boiling Point: 295.9±50.0 °C(Predicted)
• Appearance: /
• Density: 1.530±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 11.78±0.70(Predicted)
• CAS DataBase Reference: 1-(3-CHLORO-4-FLUOROPHENYL)-2-THIOUREA(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-CHLORO-4-FLUOROPHENYL)-2-THIOUREA(154371-25-2)
• EPA Substance Registry System: 1-(3-CHLORO-4-FLUOROPHENYL)-2-THIOUREA(154371-25-2)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• WGK Germany: 3
• Hazardous Substances Data: 154371-25-2(Hazardous Substances Data)

Usage

General Description

1-(3-chloro-4-fluorophenyl)-2-thiourea is a chemical compound with the molecular formula C7H6ClFN2S. It is a thiourea derivative that contains a chlorine and fluorine substituent on the phenyl ring. 1-(3-CHLORO-4-FLUOROPHENYL)-2-THIOUREA is reported to exhibit antiproliferative and cytotoxic effects in cancer cells, making it a potential candidate for cancer therapy. Additionally, it has been studied for its potential use in the treatment of autoimmune diseases and inflammatory conditions. It is important to handle this chemical with caution, as it may pose health risks if not used properly.

Upstream product

• 367-21-5 3-chloro-4-fluorophenylamine 
• 17356-08-0 thiourea 
• 431075-50-2 N-(3-chloro-5-fluorophenyl)-N'-benzoylthiourea 
• 1147550-11-5 ammonium thiocyanate 

Downstream Products

• 154371-22-9 2-(3-Chloro-4-fluoro-phenylamino)-1-thia-3,9,10-triaza-anthracen-4-one 
• 1024590-17-7 C₂₃H₁₅ClFN₃O₂S 
• 1024590-18-8 C₂₄H₁₇ClFN₃O₂S 
• 101337-92-2 2-amino-5-chloro-6-fluro[2,1-b][1,3]benzothiazole 
• 1239982-52-5 2-(3-chloro-4-fluorophenylamino)-4-(4-chlorophenyl)thiazole 
• 1198108-43-8 2-(3-chloro-4-fluorophenylamino)-4-(4-bromophenyl)thiazole 
• 1013479-56-5 ethyl 1-(3-chloro-4-fluorophenyl)-1,2,3,4-tetrahydro-6-methyl-4-(3-nitrophenyl)-2-thioxopyrimidine-5-carboxylate 
• 1013612-99-1 ethyl 1-(3-chloro-4-fluorophenyl)-1,2,3,4-tetrahydro-6-methyl-4-(2-nitrophenyl)-2-thioxopyrimidine-5-carboxylate 
• 849455-40-9 C₁₂H₁₀ClFN₂OS 
• 1266927-15-4 C₁₀H₇Cl₂FN₂S 
• 729581-03-7 C₁₈H₁₄ClFN₂O₂S 
• 956473-15-7 C₁₈H₁₃Cl₂FN₂O₂S 

Relevant articles and documents

Green and efficient synthesis of thioureas, ureas, primary: O -thiocarbamates, and carbamates in deep eutectic solvent/catalyst systems using thiourea and urea

An efficient and general catalysis process was developed for the direct preparation of various primary O-thiocarbamates/carbamates as well as monosubstituted thioureas/ureas by using thiourea/urea as biocompatible thiocarbonyl (carbonyl) sources. This procedure used choline chloride/tin(ii) chloride [ChCl][SnCl2]2 with a dual role as a green catalyst and reaction medium to afford the desired products in moderate to excellent yields. Moreover, the DES can be easily recovered and reused for seven cycles with no significant loss in its activity. Besides, the method shows very good performance for synthesizing the desired products on a large scale.

Synthesis and Cytotoxicity in Vitro of N-Aryl-4-(Tert-butyl)-5-(1H-1,2,4-triazol-1-yl)thiazol-2-amine

A series of novel N-aryl-4-(tert-butyl)-5-(1H-1,2,4-triazol-1-yl)thiazol-2-amines were synthesized in a green way. H2O2-NaBr Brominating circulatory system was used in the synthesis of the key intermediate in a mild condition. All of the target compounds were confirmed by1H NMR and elemental analysis and tested for their cytotoxicity against two different human cancer cell lines. The cytotoxicity assay revealed that some of the title compounds showed moderate to strong cytotoxic activities. Compound 2i was the most potent compound with the IC50 values of 9 μMagainst Hela cells and 15 μMagainst Bel-7402 cells, respectively.

Synthesis and in vivo diuretic activity of biphenyl benzothiazole-2- carboxamide derivatives

A series of N-{(substituted)1,3-benzothiazol-2-yl}-1,1'-biphenyl-4- carboxamides was synthesized by reaction between biphenyl acid chloride and 2-aminobenzothiazole. The synthesized compounds were screened in vivo for diuretic activity. Among the series, N-(1,3-benzothiazol-2-yl)-1,1'-biphenyl-4- carboxamide (II) was found to be the most promising candidate.