154476-57-0

Basic information

• Product Name: 1 3-BIS(TERT-BUTOXYCARBONYL)GUANIDINE
• Synonyms: 1,3-BIS(TERT-BUTOXYCARBONYL)GUANIDINE, 9 8%;N,N'-DI(TERT-BUTOXYCARBONYL)GUANIDINE;1,3-Bis(Tert-butyoxycarbonyl)guanidine;1,3-Bis(tert-butoxycarbonyl)guanidine 98%;N,N'-Bis(tert-butoxycarbonyl)guanidine
• CAS NO: 154476-57-0
• Molecular Formula: C₁₁H₂₁N₃O₄
• Molecular Weight: 259.30214
• Product Categories: Guanidines;Nitrogen Compounds;Organic Building Blocks
• Mol File: 154476-57-0.mol
• Article Data: 25

Chemical Properties

• Melting Point: 141-144 °C(lit.)
• Appearance: /
• Density: 1.13g/cm³
• Refractive Index: 1.485
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 8.24±0.46(Predicted)
• CAS DataBase Reference: 1 3-BIS(TERT-BUTOXYCARBONYL)GUANIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1 3-BIS(TERT-BUTOXYCARBONYL)GUANIDINE(154476-57-0)
• EPA Substance Registry System: 1 3-BIS(TERT-BUTOXYCARBONYL)GUANIDINE(154476-57-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 154476-57-0(Hazardous Substances Data)

Usage

Uses

1,3-Bis(tert-butoxycarbonyl)guanidine may be used to produce a guanidinyl derivative during the multi-step synthesis of (-)-crispine E. It may also be used as a reagent during the preparation of 1,6-diphenylnaphthalenes.

General Description

1,3-Bis(tert-butoxycarbonyl)guanidine is a guanidine derivative. The synthesis of N-substituted 2-aminoimidazole inhibitors using 1,3-bis(tert-butoxycarbonyl)guanidine has been reported.

InChI:InChI=1/C11H21N3O4/c1-10(2,3)17-8(15)13-7(12)14-9(16)18-11(4,5)6/h1-6H3,(H3,12,13,14,15,16)

Upstream product

• 107819-90-9 1,3-bis(tert-butoxycarbonyl)-2-methyl-2-thiopseudourea 
• 24424-99-5 di-tert-butyl dicarbonate 
• 50-01-1 guanidine hydrochloride 
• 322474-21-5 N,N'-bis-Boc-S-methyl-isothiourea 
• 867-44-7 S-Methylisothiourea sulfate 
• 145013-05-4 tert-butyl N-({[(tert-butoxy)carbonyl]amino}methanethioyl)carbamate 

Downstream Products

• 757952-42-4 C₂₀H₂₉N₃O₄ 
• 1092657-89-0 N₁,N₂-bis(tert-butyloxycarbonyl)-N₁-(1-phenyl-2-propenyl)guanidine 
• 757952-46-8 N₁,N₂-bis(tert-butyloxycarbonyl)-N₁-(1-phenyl-2-propenyl)guanidine 
• 1000875-21-7 N,N''-bis(tert-butoxycarbonyl)-N-(3-trimethylstannylbenzyl)guanidine 
• 1446863-11-1 di-N-Boc-1-((2-(4-t-butylphenyl)quinoxalin-5-yl)methyl)guanidine 

Relevant articles and documents

RETRACTED ARTICLE: Synthesis and bioevaluation of aryl-guanidino polyamine conjugates targeting the polyamine transporter

Aryl-guanidino polyamine conjugates were prepared to evaluate their recognition for polyamine transporter (PAT) via a-difluoromethylornithine (DFMO) and spermidine (SPD)-treated B16 cell lines. The potent synergistic effects of DFMO on guanidino polyamine conjugates indicated that the presence of DFMO strongly facilitates the transport of conjugates into cells via PAT on cell membrane. The apoptotic mechanisms of triamine conjugates 10 and 1 (with and without guanidine groups) revealed that they induced apoptosis of Hela cells through the mitochondrial pathway associated with lysosomes, while DFMO strongly synergizes the function of 10 without changing the apoptotic route. Taken together, guanidino polyamine conjugates can target PAT for transport as normal polyamine ones, and the presence of guanidine in the polyamine vectors does not seem to alter the cellular targets of the conjugates, which may depend mainly on the pharmacophore.

MODIFIED PEPTIDES AND THEIR USE

The invention relates to a compound of formula (A) wherein n is an integer from 1 to 6, and R1, R1', R2, R2', R3, R3' are cationic or hydrophobic residues.

ANTIBACTERIAL THERAPEUTICS AND PROPHYLACTICS

The present disclosure relates generally to novel molecules, compositions, and formulations for treatment of bacterial infections in general and more specifically to bacterial infections with antibiotic resistant pathogens.