15450-72-3

Basic information

• Product Name: (2-oxo-1H-quinolin-8-yl) acetate
• Synonyms: Carbostyril,8-hydroxy-, 8-acetate (6CI); Carbostyril, 8-hydroxy-, acetate (ester) (8CI);2,8-Quinolinediol 8-acetate; 8-Acetoxy-1H-quinolin-2-one;8-Acetoxy-2(1H)-quinolinone; 8-Acetoxy-2-hydroxyquinoline;8-Acetoxy-2-quinolinol; 8-Acetoxy-2-quinolone; 8-Acetoxycarbostyril; NSC 108382
• CAS NO: 15450-72-3
• Molecular Formula: C₁₁H₉NO₃
• Molecular Weight: 0
• Mol File: 15450-72-3.mol
• Article Data: 31

Chemical Properties

• Boiling Point: 415.1°Cat760mmHg
• Flash Point: 204.8°C
• Appearance: /
• Density: 1.272g/cm³
• Vapor Pressure: 4.24E-07mmHg at 25°C
• Refractive Index: 1.575
• CAS DataBase Reference: (2-oxo-1H-quinolin-8-yl) acetate(CAS DataBase Reference)
• NIST Chemistry Reference: (2-oxo-1H-quinolin-8-yl) acetate(15450-72-3)
• EPA Substance Registry System: (2-oxo-1H-quinolin-8-yl) acetate(15450-72-3)

Safety Data

• Hazardous Substances Data: 15450-72-3(Hazardous Substances Data)

Usage

General Description

"(2-oxo-1H-quinolin-8-yl) acetate" is a chemical compound that belongs to the quinoline family. It is an acetate derivative of 2-oxo-1H-quinoline-8-carboxylic acid and is commonly used in organic synthesis and pharmaceutical research. (2-oxo-1H-quinolin-8-yl) acetate has potential applications in the development of new drugs and pharmaceuticals due to its unique structural characteristics and biological activities. Its use in medicinal chemistry and drug design makes it an important intermediate in the creation of biologically active compounds and potential pharmaceutical agents. Additionally, it may also have uses in a variety of other chemical and industrial processes due to its versatile nature and reactivity.

InChI:InChI=1/C11H9NO3/c1-7(13)15-9-4-2-3-8-5-6-10(14)12-11(8)9/h2-6H,1H3,(H,12,14)

Upstream product

• 15450-76-7 quinoline-2,8-diol 
• 108-24-7 acetic anhydride 
• 1127-45-3 8-Hydroxyquinoline-N-oxide 
• 148-24-3 8-quinolinol 
• 15450-76-7 8-Hydroxy-1H-quinolin-2-one 
• 2598-29-0 8-acetyloxyquinoline 
• 103368-17-8 Acetic acid 1-oxy-quinolin-8-yl ester 
• 84-88-8 8-quinolinol-5-sulfonic acid 

Downstream Products

• 201301-82-8 8-acetoxy-2-[2-(4-phenylphenyl)-2-oxoethoxy]quinoline 
• 15450-76-7 8-Hydroxy-1H-quinolin-2-one 
• 956235-09-9 5-acetyl-8-[(4-methoxyphenyl)methoxy]-1,2-dihydroquinolin-2-one 
• 1254102-83-4 5-(2-bromoacetyl)-8-[(4-methoxyphenyl)methoxy]-1,2-dihydroquinolin-2-one 
• 1254102-84-5 5-[(1R)-2-bromo-1-hydroxyethyl]-8-[(4-methoxyphenyl)methoxy]-1,2-dihydroquinolin-2-one 
• 1254098-87-7 4-[({5-[2-({[4-({[(2R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}methyl)phenyl]methyl}carbamoyl)ethyl]-2-phenylphenyl}carbamoyl)oxy]-1,1-dimethylpiperidin-1-ium trifluoroacetate 
• 93609-84-8 5-acetyl-8-benzyloxy-1H-quinolin-2-one 
• 100331-89-3 8-benzyloxy-5-(2-bromoacetyl)-1H-quinolin-2-one 
• 31568-91-9 2-chloroquinolin-8-ol 
• 199871-96-0 2--bromo--8--methoxyquinoline 
• 343788-51-2 8-(benzyloxy)-2-chloroquinoline 
• 63404-84-2 8-(benzyloxy)quinolin-2(1H)-one 
• 1254103-10-0 4-({[5-(9-[{(2R)-[8-(benzyloxy)-2-oxo-1,2-dihydroquinolin-5-yl]-2-hydroxyethyl}amino]nonyl)-2-phenylphenyl]carbamoyl}oxy)-1,1-dimethylpiperidin-1-ium trifluoroacetate 
• 1254099-09-6 4-({[5-(9-{[(2R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}nonyl)-2-phenylphenyl]carbamoyl}oxy)-1,1-dimethylpiperidin-1-ium trifluoroacetate 

Relevant articles and documents

Selenophenol quinoline derivative as well as preparation method and application thereof

The invention discloses a selenophenol quinoline derivative as well as a preparation method and application thereof. The structure of the selenophenol quinoline derivative is shown as a formula I, a formula II or a formula III, wherein R1 is hydrogen, a C1-6 alkyl group, a C1-6 alkoxy group, a substituted ketone group, a phenyl group, a benzyl group, a substituted phenyl group or a substituted benzyl group; R1 is a monovalent metal cation; R2 is one or more of hydrogen, halogen, a C1-4 alkyl group, a C1-4 alkoxy group or a C1-4 haloalkyl group; R3 is a substituted five-membered heterocyclicring or a substituted six-membered heterocyclic ring; and a heteroatom is one or more of N, O, S or Se. The compound disclosed by the invention is novel in structure, simple in preparation process and relatively good in inhibition effect on various cancer cells, particularly the compounds 34, 44, 45, 98, 104, 115 and 116 have excellent inhibition effects on various cancer cells, the effects of the compounds are equivalent to those of a positive control DDP, and the compounds can be used to prepare anti-cancer drugs to be applied under 5 [mu]M or below, so that the prospect is wide.

Novel 2, 8-bit derivatives of quinolines attenuate Pseudomonas aeruginosa virulence and biofilm formation

Signal molecules are stimulators of multiple quroum-sensing virulence and biofilm formation. Small molecule analogues have been suspected as a potent inhibitor in therapeutic strategy. Herein, we synthesized a series of small molecule compounds from the 2