15462-43-8

Basic information

• Product Name: 2-CYANO-3-HYDROXYQUINOLINE
• Synonyms: 2-CYANO-3-HYDROXYQUINOLINE;3-Hydroxyquinaldonitrile;3-Hydroxyquinoline-2-carbonitrile
• CAS NO: 15462-43-8
• Molecular Formula: C10H6N2O
• Molecular Weight: 170.16744
• Mol File: 15462-43-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 389.3 °C at 760 mmHg
• Flash Point: 189.2 °C
• Appearance: /
• Density: 1.36 g/cm³
• Vapor Pressure: 1.28E-06mmHg at 25°C
• Refractive Index: 1.702
• CAS DataBase Reference: 2-CYANO-3-HYDROXYQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CYANO-3-HYDROXYQUINOLINE(15462-43-8)
• EPA Substance Registry System: 2-CYANO-3-HYDROXYQUINOLINE(15462-43-8)

Safety Data

• Hazardous Substances Data: 15462-43-8(Hazardous Substances Data)

Usage

General Description

2-Cyano-3-hydroxyquinoline is a chemical compound that belongs to the class of quinolines. It is a yellowish crystalline solid that is commonly used as a fluorescent dye and as an intermediate in the synthesis of pharmaceuticals and other organic compounds. 2-CYANO-3-HYDROXYQUINOLINE has antioxidant properties and has been studied for its potential use in the treatment of neurodegenerative diseases such as Alzheimer's. It is also used in the production of sensors and indicators for metal ions and has been investigated for its antibacterial and antifungal activities. Additionally, 2-cyano-3-hydroxyquinoline has been studied for its potential application in analytical chemistry and environmental monitoring due to its ability to detect and quantify certain analytes.

InChI:InChI=1/C10H6N2O/c11-6-9-10(13)5-7-3-1-2-4-8(7)12-9/h1-5,13H

Upstream product

• 151-50-8 potassium cyanide 
• 59953-98-9 3-hydroxyquinoline-1-oxide 

Relevant articles and documents

Desazadesmethyldesferrithiocin analogues as orally effective iron chelators

Further structure-activity studies of desferrithiocin analogues are carried out. (S)-Desazadesmethyldesferrithiocin, 2-(2-hydroxyphenyl)-Δ2- thiazoline-4(S)-carboxylic acid, serves as the principal framework in the current paper. Desazadesmethyldesferrithiocin can be structurally altered with facility, and data are already available on its iron-clearing properties and toxicity parameters. Four different kinds of structural modifications of this framework are undertaken: introduction of hydroxy, carboxy, or methoxy groups on the aromatic ring; alteration of the thiazoline ring; increasing the distance between the ligand donor atoms; and benz-fusion of the aromatic rings. The structural modifications described are shown to have a tremendous impact on both the iron clearance and toxicity profiles of the desazadesmethyldesferrithiocin molecule. All of the compounds are assessed in a bile-duct-cannulated rodent model to determine iron clearance efficiency. Ligands which demonstrate an efficiency of greater than 2% are carried forward to the iron-overloaded primate for iron-clearing measurements. Ligands with efficiencies greater than 3% in the primate are then evaluated in a formal toxicity study in rodents. On the basis of the results of the present work, 2-(2,4-dihydroxyphenyl)-Δ2-thiazoline-4(S)-carboxylic acid is a promising candidate for clinical evaluation.