154630-93-0

Basic information

• Product Name: ()-2-(TRIFLUOROMETHYL)PIPERIDINE
• Synonyms: ()-2-(TRIFLUOROMETHYL)PIPERIDINE
• CAS NO: 154630-93-0
• Molecular Formula: C6H10F3N
• Molecular Weight: 153.15
• Mol File: 154630-93-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 118.4°C at 760 mmHg
• Flash Point: 27℃
• Appearance: /
• Density: 1.126 g/mL at 25 °C
• Vapor Pressure: 16.7mmHg at 25°C
• Refractive Index: n20/D1.390
• PKA: 7.74±0.10(Predicted)
• CAS DataBase Reference: ()-2-(TRIFLUOROMETHYL)PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: ()-2-(TRIFLUOROMETHYL)PIPERIDINE(154630-93-0)
• EPA Substance Registry System: ()-2-(TRIFLUOROMETHYL)PIPERIDINE(154630-93-0)

Safety Data

• Hazard Codes: Xi,N,Xn
• Statements: 10-22-36/37/38-50
• Safety Statements: 26-36/37/39-45-61
• RIDADR: UN 1993C 3 / PGIII
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 154630-93-0(Hazardous Substances Data)

Usage

General Description

()-2-(trifluoromethyl)piperidine is a chemical compound with the formula C6H10F3N. It is a piperidine derivative, which is a six-membered heterocyclic organic compound containing a nitrogen atom. The trifluoromethyl group (-CF3) is a functional group consisting of three fluorine atoms bonded to a single carbon atom. ()-2-(TRIFLUOROMETHYL)PIPERIDINE is used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It is also used in research as a precursor for the preparation of other organic compounds. The trifluoromethyl group can contribute to the lipophilicity and metabolic stability of the resulting compounds, making them potentially useful in drug development. Overall, ()-2-(trifluoromethyl)piperidine is a versatile compound with wide-ranging applications in the chemical and pharmaceutical industries.

InChI:InChI=1/C6H10F3N/c7-6(8,9)5-3-1-2-4-10-5/h5,10H,1-4H2

Upstream product

• 368-48-9 2-(trifluoromethyl)pyridine 
• 1146222-76-5 6-(trifluoromethyl)-2,3,4,5-tetrahydropyridine 
• 863982-49-4 (+/-)-8-(trifluoromethyl)-1,5-dioxa-9-azaspiro[5.5]undecane 
• 627533-08-8 2-(trifluoromethyl)piperidine hydrochloride 
• 522-33-8 Tripiperidin 
• 81290-20-2 (trifluoromethyl)trimethylsilane 

Relevant articles and documents

HYDROGENATION PROCESS OF OXIME DERIVATIVES

The present invention relates to a novel process for the iridium-catalysed hydrogenation of oximes. The invention also relates to novel iridium catalysts for use in the iridium-catalysed hydrogenation of oximes and to processes of preparation of these cat

Method for synthesizing cis-trifluoromethylcyclohexane derivatives and heterocyclic compounds by hydrogenation

The invention discloses a method for synthesizing cis-trifluoromethylcyclohexane derivatives and heterocyclic compounds by hydrogenation. The method is characterized in that trifluoromethylaromatic hydrocarbons or trifluoromethyl heterocyclic compounds ar

Practical synthesis of α-perfluoroalkyl cyclic imines and amines

A convenient and simple approach for the preparation of -CF3and C2F5 substituted pyrrolines, tetrahydropyridines, tetrahydroazepine is described. Claisen condensation of N-protected cyclic amides with esters of perfluorocarboxylic acids followed by deprotection and decarboxylation in acidic media leads to the desired products. Reduction of these imines permits to obtain 5-, 6-, and 7-membered cyclic amines with - CF3and C2F5 group in good to moderate overall yields. Georg Thieme Verlag Stuttgart - New York.