154750-11-5

Basic information

• Product Name: 5-phenyl-1-trityl-1H-tetrazole
• Synonyms: 5-phenyl-1-trityl-1H-tetrazole;2-Formyl-4-hydroxy-5-methoxyphenylboronic acid, pinacol ester
• CAS NO: 154750-11-5
• Molecular Formula: C₂₆H₂₀N₄
• Molecular Weight: 388.4638
• Mol File: 154750-11-5.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 586.1±60.0 °C(Predicted)
• Appearance: /
• Density: 1.14±0.1 g/cm3(Predicted)
• PKA: 0.37±0.10(Predicted)
• CAS DataBase Reference: 5-phenyl-1-trityl-1H-tetrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-phenyl-1-trityl-1H-tetrazole(154750-11-5)
• EPA Substance Registry System: 5-phenyl-1-trityl-1H-tetrazole(154750-11-5)

Safety Data

• Hazardous Substances Data: 154750-11-5(Hazardous Substances Data)

Upstream product

• 18039-42-4 5-Phenyl-1H-tetrazole 
• 76-83-5 trityl chloride 
• 100-47-0 benzonitrile 

Downstream Products

• 144873-97-2 2-(N-triphenylmethyl-tetrazol-5-yl)-phenylboronic acid 
• 781664-81-1 N-[[2'-(1-triphenylmethyltetrazol-5yl)biphenyl-4-yl]methyl]-N-valeryl-L-valine methyl ester 
• 18039-42-4 5-Phenyl-1H-tetrazole 
• 124750-53-4 N-triphenylmethyl-5-(4'-methylbiphenyl-2-yl)tetrazole 
• 1301768-36-4 C₂₄⁽¹⁴⁾CH₂₈N₆O 
• 178859-88-6 5-ethyl-2-trifluoroacetylimino-3-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl-1,3,4-thiadiazoline 

Relevant articles and documents

Zn/MeOH-Mediated Practical and Easy Detritylation of Protected 1-Trityltetrazoles

A practical and low-cost method for the detritylation of 1-titryltetrazoles using zinc and methanol is described. This procedure is versatile and efficient in the deprotection of several protected tetrazoles bearing aliphatic, aromatic, and heteroaromatic substituents, as well as some functional groups, without decomposition of the tetrazole ring.

Detritylation of protected tetrazoles by naphthalene-catalyzed lithiation

Treatment of N-tritylated tetrazoles bearing aliphatic, aromatic, or heteroaromatic substituents (including functionalized ones) with lithium powder and a catalytic amount of naphthalene led to reductive removal of the trityl group to give excellent yields of the corresponding free tetrazoles without decomposition of the tetrazole ring. The detritylation process was successfully extended to several tetrazoles that are components of sartans, an interesting class of drugs. The chemoselectivity between trityl-tetrazole and trityl-amine bond-cleavage reactions was also studied. This method represents an efficient technique for deprotection of tritylated tetrazoles under non-acidic conditions. Georg Thieme Verlag Stuttgart, New York.

DUAL-ACTING OXAZOLE ANTIHYPERTENSIVE AGENTS

In one aspect, the invention relates to compounds having the formula: wherein: Ar, Z, R3, R4 and R5 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 re