154822-28-3

Basic information

• Product Name: 3-hydroxy-3-(pyridin-2-yl)-5-methoxy-2-phenyl-2,3-dihydro-1H-isoindol-1-one
• CAS NO: 154822-28-3
• Molecular Weight: 332.359
• Mol File: 154822-28-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-hydroxy-3-(pyridin-2-yl)-5-methoxy-2-phenyl-2,3-dihydro-1H-isoindol-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-3-(pyridin-2-yl)-5-methoxy-2-phenyl-2,3-dihydro-1H-isoindol-1-one(154822-28-3)
• EPA Substance Registry System: 3-hydroxy-3-(pyridin-2-yl)-5-methoxy-2-phenyl-2,3-dihydro-1H-isoindol-1-one(154822-28-3)

Safety Data

• Hazardous Substances Data: 154822-28-3(Hazardous Substances Data)

Upstream product

• 2459-07-6 methyl pyridine-2-carboxylate 
• 7465-88-5 4-methoxy-N-phenylbenzamide 
• 14805-91-5 N,N-dimethylpicolinamide 

Relevant articles and documents

Application of organolithium and related reagents in synthesis. Part 14. Synthetic strategies based on aromatic metallation. A concise regiospecific conversion of benzole acids into their ortho-pyridoyl derivatives

The synthesis of the 3-hydroxy-3-pyridyl-isoindolin-1-ones (5) and (6) via metallation (n-BuLi) of the benzanilides (1), and then the reaction of the generated bis lithiated anilides (2) with N,N-dimethylamides or methyl esters of pyridinecarboxylic acids (benzoylation reagents), and subsequent acidic hydrolysis of (5) and (6) as a way (general synthetic strategy) of regiospecific transformation of benzoic acids into their ortho-benzoylated derivatives, is described.