154866-94-1Relevant articles and documents
Microwave-assisted synthesis of some BI- and tricyclic pyrimidine derivatives
Foroughifar,Mobinikhaledi,Jirandehi, H. Fathinejad,Memar
, p. 1269 - 1276 (2007/10/03)
Pyrimidine derivatives 4a-4c was prepared by a Biginelli cyclocondensation of β-ketoesters, aryl aldehydes, and thiourea derivatives under microwave irradiation. A simple and fast synthesis of bicyclic pyrimidine derivatives 6a-6c was performed by microwave-assisted reaction of 4a-4c with bromomalononitrile (5). Reaction of bicyclic pyrimidines 6a-6c with HCO2H and HONH3Cl under microwave irradiation gave tricyclic pyrimidines 7a-7c and 8a-8c respectively.